A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction

Venero, Carmelo V.; Heller, Gary V.; Bateman, Timothy M.; McGhie, A. Iain; Ahlberg, Alan W.; Katten, Deborah; Courter, Staci; Golub, R.; Case, James A.; Cullom, S. James

doi:10.1007/s12350-009-9106-9

Cited by 94 publications

(42 citation statements)

References 18 publications

(16 reference statements)

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“…First, SPECT studies in CORE320, although obtained at validated laboratories, did not use attenuation correction. Attenuation correction has been shown to improve specificity, but is not yet in widespread use (26). Although this is a limitation, our study reflects contemporary clinical SPECT standards throughout four continents and eight nations and highlights the importance of attenuation correction.…”

Section: Disclosures Of Conflicts Of Interest: Rtgmentioning

confidence: 82%

Myocardial CT Perfusion Imaging and SPECT for the Diagnosis of Coronary Artery Disease: A Head-to-Head Comparison from the CORE320 Multicenter Diagnostic Performance Study

George¹,

Mehra²,

Chen³

et al. 2014

Radiology

103

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Purpose:To compare the diagnostic performance of myocardial computed tomographic (CT) perfusion imaging and single photon emission computed tomography (SPECT) perfusion imaging in the diagnosis of anatomically significant coronary artery disease (CAD) as depicted at invasive coronary angiography. Materials and Methods:This study was approved by the institutional review board. Written informed consent was obtained from all patients. Sixteen centers enrolled 381 patients from November 2009 to July 2011. Patients underwent rest and adenosine stress CT perfusion imaging and rest and either exercise or pharmacologic stress SPECT before and within 60 days of coronary angiography. Images from CT perfusion imaging, SPECT, and coronary angiography were interpreted at blinded, independent core laboratories. The primary diagnostic parameter was the area under the receiver operating characteristic curve (A z ). Sensitivity and specificity were calculated with use of prespecified cutoffs.The reference standard was a stenosis of at least 50% at coronary angiography as determined with quantitative methods. Results:CAD was diagnosed in 229 of the 381 patients (60%). The per-patient sensitivity and specificity for the diagnosis of CAD (stenosis 50%) were 88% (202 of 229 patients) and 55% (83 of 152 patients), respectively, for CT perfusion imaging and 62% (143 of 229 patients) and 67% (102 of 152 patients) for SPECT, with A z values of 0.78 (95% confidence interval: 0.74, 0.82) and 0.69 (95% confidence interval: 0.64, 0.74) (P = .001). The sensitivity of CT perfusion imaging for single-and multivessel CAD was higher than that of SPECT, with sensitivities for left main, threevessel, two-vessel, and one-vessel disease of 92%, 92%, 89%, and 83%, respectively, for CT perfusion imaging and 75%, 79%, 68%, and 41%, respectively, for SPECT. Conclusion:The overall performance of myocardial CT perfusion imaging in the diagnosis of anatomic CAD (stenosis 50%), as demonstrated with the A z , was higher than that of SPECT and was driven in part by the higher sensitivity for left main and multivessel disease.q RSNA, 2014

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Section: Disclosures Of Conflicts Of Interest: Rtgmentioning

confidence: 82%

Myocardial CT Perfusion Imaging and SPECT for the Diagnosis of Coronary Artery Disease: A Head-to-Head Comparison from the CORE320 Multicenter Diagnostic Performance Study

George¹,

Mehra²,

Chen³

et al. 2014

Radiology

103

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“…To our knowledge this is the first publication presenting not only agreement between results of full and reduced count studies processed with "Evolution for Cardiac" software package, but also comparing their diagnostic efficacy with and without attenuation correction. Other results of works comparing diagnostic efficacy of full and reduced count studies can be found in the literature [11,12], but they do not concern "Evolution for Cardiac" software.…”

Section: Originalmentioning

confidence: 99%

Reduced-time myocardial perfusion study processed with “Myovation Evolution” — assessment of diagnostic efficacy

et al. 2017

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“…In addition, newer SPECT attenuation correction algorithms such as FLASH-3D and Astonish can achieve near PET-like image quality. 18,19 Because of this, the American Society of Nuclear Cardiology and Society of Nuclear Medicine have issued a joint statement on attenuation correction recommending it when possible. 20 This has led many of the leading nuclear laboratories to acquire SPECT line sources and SPECT/CT adopt attenuation correction in all SPECT nuclear cardiology studies.…”

Section: Value Of Attenuation Correctionmentioning

confidence: 99%

A multicenter evaluation of a new post-processing method with depth-dependent collimator resolution applied to full-time and half-time acquisitions without and with simultaneously acquired attenuation correction

Cited by 94 publications

References 18 publications

Myocardial CT Perfusion Imaging and SPECT for the Diagnosis of Coronary Artery Disease: A Head-to-Head Comparison from the CORE320 Multicenter Diagnostic Performance Study

Myocardial CT Perfusion Imaging and SPECT for the Diagnosis of Coronary Artery Disease: A Head-to-Head Comparison from the CORE320 Multicenter Diagnostic Performance Study

Reduced-time myocardial perfusion study processed with “Myovation Evolution” — assessment of diagnostic efficacy

Minimizing the radiation dose of CT attenuation correction while improving image quality: The case for innovation

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