A Multicenter Clinical Trial of TJ‐96 in Patients with Steroid‐Dependent Bronchial Asthma A Comparison of Groups Allocated by the Envelope Method

Egashira, Yosuke; Nagano, Hitoshi

doi:10.1111/j.1749-6632.1993.tb35921.x

Cited by 30 publications

(13 citation statements)

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“…It is a combination of two herbal preparations containing 10 herbs19 and has been used in China for steroid dependent asthma resulting in a steroid sparing effect. Despite its intensive use, there is only one randomised clinical trial in the literature from Japan 20. This 12 week study involved 112 adults with steroid dependent bronchial asthma.…”

Section: Resultsmentioning

confidence: 99%

“…Four of the trials with T indica 14-17 and the TJ-96 study20 resulted in a significant improvement in asthma symptoms. L wallichii ,5 SBR and RKISP decoctions,6-7 P kurroa ,10 Solanum sp,11 one trial with T indica ,18 and marihuana24 did not produce any clinically relevant or statistically significant improvement in lung function or asthma symptoms compared with the control.…”

Section: Discussionmentioning

confidence: 96%

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Herbal medicines for asthma: a systematic review

Huntley

Ernst

2000

Thorax

146

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Background-Asthma is one of the most common chronic diseases in modern society and there is increasing evidence to suggest that its incidence and severity are increasing. There is a high prevalence of usage of complementary medicine for asthma. Herbal preparations have been cited as the third most popular complementary treatment modality by British asthma suVerers. This study was undertaken to determine if there is any evidence for the clinical eYcacy of herbal preparations for the treatment of asthma symptoms. Methods-Four independent literature searches were performed on Medline, Pubmed, Cochrane Library, and Embase. Only randomised clinical trials were included. There were no restrictions on the language of publication. The data were extracted in a standardised, predefined manner and assessed critically. Results-Seventeen randomised clinical trials were found, six of which concerned the use of traditional Chinese herbal medicine and eight described traditional Indian medicine, of which five investigated Tylophora indica. Three other randomised trials tested a Japanese Kampo medicine, marihuana, and dried ivy leaf extract. Nine of the 17 trials reported a clinically relevant improvement in lung function and/or symptom scores. Conclusions-No definitive evidence for any of the herbal preparations emerged. Considering the popularity of herbal medicine with asthma patients, there is urgent need for stringently designed clinically relevant randomised clinical trials for herbal preparations in the treatment of asthma. (Thorax 2000;55:925-929)

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Herbal medicines for asthma: a systematic review

Huntley

Ernst

2000

Thorax

146

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“…8 Honokiol is one of the active compounds in the Japanese herbal medicine, Saiboku-to, which has traditionally been consumed as a tea for its antianxiety effects and has undergone clinical evaluation in Japan for the treatment of asthma. 46 Symptomatic improvement was reported in the honokiol-treated asthma patients; however, higher-quality clinical trials that address both the efficacy as well as the potential adverse effects that occur with the use of herbal medicines are needed.…”

Section: Discussionmentioning

confidence: 99%

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells

Battle

Arbiser

Frank

2005

Blood

181

161

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“…Our previous pharmacokinetic studies (25) in mice revealed that honokiol was readily absorbed and maintained in the plasma for >10 h. The plasma concentration attainable in mice in vivo was 1,000 Ag/mL at a dose of 250 mg/kg of honokiol via gastric intubation, significantly exceeding the levels that were toxic to tumor cells in vitro (25,47). The safety of honokiol is indirectly reflected by the facts that Hou-pu, a Magnolia species, from which honokiol is extracted, is listed in the Chinese Pharmacopoeia and indexed as a tonic, sedative, and blood-activating and stasis-dissolving prescription, and that Saiboku-to, synonymous with Hou-pu in Japan, has entered clinical trials in Japan for the treatment of asthma (48).…”

Section: Discussionmentioning

confidence: 99%

Honokiol Induces a Necrotic Cell Death through the Mitochondrial Permeability Transition Pore

Li¹,

Han²,

et al. 2007

Cancer Research

100

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Previous reports have shown that honokiol induces apoptosis in numerous cancer cell lines and showed preclinical efficacies against apoptosis-resistant B-cell chronic lymphocytic leukemia and multiple myeloma cells from relapserefractory patients. Here, we show that honokiol can induce a cell death distinct from apoptosis in HL60, MCF-7, and HEK293 cell lines. The death was characterized by a rapid loss of integrity of plasma membrane without externalization of phosphatidyl serine. The broad caspase inhibitor z-VADfmk failed to prevent this cell death. Consistently, caspase activation and DNA laddering were not observed. The death was paralleled by a rapid loss of mitochondrial membrane potential, which was mechanistically associated with the mitochondrial permeability transition pore regulated by cyclophilin D (CypD) based on the following evidence: (a) cyclosporin A, an inhibitor of CypD (an essential component of the mitochondrial permeability transition pore), effectively prevented honokiol-induced cell death and loss of mitochondrial membrane potential; (b) inhibition of CypD by RNA interference blocked honokiol-induced cell death; (c) CypD up-regulated by honokiol was correlated with the death rates in HL60, but not in K562 cells, which underwent apoptosis after being exposed to honokiol. We further showed that honokiol induced a CypD-regulated death in primary human acute myelogenous leukemia cells, overcame Bcl-2 and Bcl-X L -mediated apoptotic resistance, and was effective against HL60 cells in a pilot in vivo study. To the best of our knowledge, this is the first report to document an induction of mitochondrial permeability transition pore-associated cell death by honokiol. [Cancer Res 2007;67(10):4894-903]

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A Multicenter Clinical Trial of TJ‐96 in Patients with Steroid‐Dependent Bronchial Asthma A Comparison of Groups Allocated by the Envelope Method

Cited by 30 publications

References 0 publications

Herbal medicines for asthma: a systematic review

Herbal medicines for asthma: a systematic review

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells

Honokiol Induces a Necrotic Cell Death through the Mitochondrial Permeability Transition Pore

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