A Multicellular Network Mechanism for Temperature-Robust Food Sensing

Patel, Dhaval; Diana, Giovanni; Entchev, Eugeni V.; Zhan, Min; Lu, Hang; Ch'ng, Quee-Lim

doi:10.1016/j.celrep.2020.108521

Cited by 2 publications

(1 citation statement)

References 59 publications

(139 reference statements)

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“…Because food levels affected the H 2 O 2 -induced food leaving behavior of C. elegans , we speculated that this behavior may be regulated by the neurotransmitter serotonin. Expression of the serotonin biosynthetic tryptophan hydroxylase gene tph-1 increases with food (Cunningham et al, 2012; Entchev et al, 2015; Liang et al, 2006; Patel et al, 2020; Sze et al, 2000; Zheng et al, 2005) and serotonin regulates many food-related behaviors (Liang et al, 2006; Melo and Ruvkun, 2012; Sze et al, 2000; Zheng et al, 2005). We found that tph-1(mg280) null mutants, which specifically lack serotonin (Sze et al, 2000), were more likely than wild-type animals to leave a lawn of E. coli JI377 when 1 mM H 2 O 2 was added to the environment (Figure 3A).…”

Section: Resultsmentioning

confidence: 99%

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Schiffer

Stumbur

Seyedolmohadesin

et al. 2021

Preprint

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Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show that H2O2 alters the bacterial food preference of Caenorhabditis elegans, enabling the nematodes to find a safe environment with food. H2O2 induces the nematodes to leave food patches of laboratory and microbiome bacteria when those bacterial communities have insufficient H2O2-degrading capacity. The nematode's behavior is directed by H2O2-sensing neurons that promote escape from H2O2 and by bacteria-sensing neurons that promote attraction to bacteria. However, the input for H2O2-sensing neurons is removed by bacterial H2O2-degrading enzymes and the bacteria-sensing neurons' perception of bacteria is prevented by H2O2. The resulting cross-attenuation provides a general mechanism that ensures the nematode's behavior is faithful to the lethal threat of hydrogen peroxide, increasing the nematode's chances of finding a niche that provides both food and protection from hydrogen peroxide.

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Section: Resultsmentioning

confidence: 99%

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Schiffer

Stumbur

Seyedolmohadesin

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Schiffer¹,

Stumbur²,

Seyedolmohadesin³

et al. 2021

PLoS Pathog

View full text Add to dashboard Cite

Hydrogen peroxide (H2O2) is the most common chemical threat that organisms face. Here, we show that H2O2 alters the bacterial food preference of Caenorhabditis elegans, enabling the nematodes to find a safe environment with food. H2O2 induces the nematodes to leave food patches of laboratory and microbiome bacteria when those bacterial communities have insufficient H2O2-degrading capacity. The nematode’s behavior is directed by H2O2-sensing neurons that promote escape from H2O2 and by bacteria-sensing neurons that promote attraction to bacteria. However, the input for H2O2-sensing neurons is removed by bacterial H2O2-degrading enzymes and the bacteria-sensing neurons’ perception of bacteria is prevented by H2O2. The resulting cross-attenuation provides a general mechanism that ensures the nematode’s behavior is faithful to the lethal threat of hydrogen peroxide, increasing the nematode’s chances of finding a niche that provides both food and protection from hydrogen peroxide.

show abstract

A Multicellular Network Mechanism for Temperature-Robust Food Sensing

Cited by 2 publications

References 59 publications

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide

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