A multibiomarker approach to explore interactive effects of propranolol and fluoxetine in marine mussels

Franzellitti, Silvia; Buratti, Sara; Du, Bowen; Haddad, Samuel P.; Chambliss, C. Kevin; Brooks, Bryan W.; Fabbri, Elena

doi:10.1016/j.envpol.2015.05.020

Cited by 44 publications

(20 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addressing anthropogenic threats to the coastal marine environment, Crain et al included pollution within the most widespread and pressing threats, together with overexploitation, habitat loss, invasive species, and intrinsic factors, based on species‐level assessments. The relative importance of pharmaceuticals among other environmental pollutants cannot be stated at the moment; however, pharmaceuticals can induce profound biological effects and thus may act as additional stressors on marine ecosystems already impacted by other factors. Modifications of pH and temperature associated with climate change influence the chemical properties of most pharmaceuticals, which therefore may contribute differently to the global effect .…”

Section: Introductionmentioning

confidence: 99%

“…Unlike conventional pollutants, pharmaceuticals are biologically active compounds designed to interact with specific physiological pathways in the target organism. Thus, they represent a class of emerging compounds able to affect specific animal functions (e.g., development, growth, and reproduction) at environmentally relevant concentrations .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Fabbri

Franzellitti

2015

Enviro Toxic and Chemistry

Self Cite

206

View full text Add to dashboard Cite

Marine waters have been poorly investigated for the occurrence of pharmaceutical contamination. Recent data confirm that pharmaceuticals occur widely in marine and coastal environments; therefore, assessment of potential risk to marine species needs further efforts. The present study represents the first extensive review of pharmaceutical contamination in marine environments addressing the effects on the marine biota analyzed at the molecular, cellular, and individual levels. Because pharmaceuticals differ from conventional pollutants, being designed to interact with specific physiological pathways at low doses, the most recent evidence on modes of action and physiological alterations on marine animal species are discussed. Data on spatial distributions of pharmaceuticals in waters and sediments, as well as bioaccumulation rates, are also presented. The present review also seeks to expand knowledge of how the quality of coastal and marine environments could be efficiently monitored to anticipate possible health and environmental risks. Environ Toxicol Chem 2016;35:799-812. # 2015 SETAC

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Fabbri

Franzellitti

2015

Enviro Toxic and Chemistry

Self Cite

206

View full text Add to dashboard Cite

show abstract

“…So far, few studies have investigated the interactions of pharmaceutical mixtures on their bioaccumulation in aquatic organisms. Franzellitti et al [22] found that fluoxetine co-exposure facilitated the bioaccumulation of propranolol in marine mussels ( Mytilus galloprovincialis ). More recently, Ding et al [23] reported that the addition of fluoxetine increased the accumulation of roxithromycin and propranolol in crucian carp ( Carassius auratus ).…”

Section: Resultsmentioning

confidence: 99%

Interactive Effects of Sertraline and Diphenhydramine on Biochemical and Behavioral Responses in Crucian Carp (Carassius auratus)

Xie

2019

IJERPH

View full text Add to dashboard Cite

The ecotoxicity of psychiatric pharmaceuticals to aquatic organisms is being increasingly recognized. However, current ecological studies focus on the effects of individual psychiatric pharmaceuticals, with little attention being given to their combined effects. In this study, the interactive effects of two psychiatric pharmaceuticals, sertraline (SER) and diphenhydramine (DPH), on bioconcentration and biochemical and behavioral responses were investigated in crucian carp (Carassius auratus) after seven days of exposure. DPH was found to increase the accumulation of SER in fish tissues relative to SER-alone exposure. In addition, the mixture of SER and DPH significantly changed the activities of antioxidant enzymes and led to significant increases in malondialdehyde content, relative to SER alone. Concerning the neurotoxicity, relative to SER-alone exposure, brain AChE activity was significantly enhanced in fish following the combined exposure. Regarding behavioral responses, swimming activity and shoaling behavior were significantly altered in co-exposure treatments compared with the SER alone. Moreover, the inhibition effects on the feeding rates were increased in co-exposure treatments compared to SER alone. Collectively, our results suggest that the mixtures of psychiatric pharmaceuticals may pose more severe ecological risks to aquatic organisms compared to these compounds individually.

show abstract

“…Along with their adrenergic antagonistic properties, first-generation antihypertensives have also been documented to possess antagonistic properties toward serotonin receptors (Huggett et al 2002). When CECs enter aquatic ecosystems, interactions among multiple prescription drugs at the molecular level may result in physiological effects at the organism level even at low exposure concentrations (Franzellitti et al 2015). There is also evidence for the occurrence of pharmaceutical compounds in aquatic organisms, including bivalves, which raises concerns around human consumption of bivalves as seafood (McEneff et al 2014;Álvarez-Muñoz et al 2015).…”

Section: Filter-feedingmentioning

confidence: 99%

Application of Biomarker Tools Using Bivalve Models Toward the Development of Adverse Outcome Pathways for Contaminants of Emerging Concern

Khan

Burgess

2020

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

As contaminant exposures in aquatic ecosystems continue to increase, the need for streamlining research efforts in environmental toxicology using predictive frameworks also grows. One such framework is the adverse outcome pathway (AOP). An AOP framework organizes and utilizes toxicological information to connect measurable molecular endpoints to an adverse outcome of regulatory relevance via a series of events at different levels of biological organization. Molecular endpoints or biomarkers are essential to develop AOPs and are valuable early warning signs of the toxicity of pollutants, including contaminants of emerging concern. Ecological risk-assessment approaches using tools such as biomarkers and AOPs benefit from identification of molecular targets conserved across species. Bivalve models are useful in such approaches and integral to our understanding of ecological and human health risks associated with contaminant exposures. We discuss the value of using biomarker approaches in bivalve models to meet the demands of twenty-first-century toxicology.

show abstract

A multibiomarker approach to explore interactive effects of propranolol and fluoxetine in marine mussels

Cited by 44 publications

References 72 publications

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Human pharmaceuticals in the marine environment: Focus on exposure and biological effects in animal species

Interactive Effects of Sertraline and Diphenhydramine on Biochemical and Behavioral Responses in Crucian Carp (Carassius auratus)

Application of Biomarker Tools Using Bivalve Models Toward the Development of Adverse Outcome Pathways for Contaminants of Emerging Concern

Contact Info

Product

Resources

About