A multi-virus detectable microfluidic electrochemical immunosensor for simultaneous detection of H1N1, H5N1, and H7N9 virus using ZnO nanorods for sensitivity enhancement

Han, Ji Hoon; Lee, Dongyoung; Chew, Charleson Hong Chuang; Kim, Taeheon; Pak, James Jungho

doi:10.1016/j.snb.2015.07.068

Cited by 108 publications

(85 citation statements)

References 26 publications

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“…A number of works published on the direct immobilization of biomolecules on the ZnO surface refers to the electrostatic interaction between ZnO and the adsorbed species [86,90,32,52]. Klaumunzer et al reported on BSA adsorption on the ZnO nanostructures.…”

Section: Direct Immobilization Of Biomolecules On Top Of Zno Nanostrumentioning

confidence: 99%

“…Various types of ZnO platforms that used as a biosensor basis have been developed [40,41,43,57,63,64,69,73,89,90,92,[94][95][96][97][98][99]. The growth-controlled synthesis of ZnO nanorods in the aqueous phase has been investigated by Balaguera-Gelves et al [40].…”

Section: Novel Trends In Zno Biosensor Platformsmentioning

confidence: 99%

“…It is known, that ZnO nanostructures can be formed using different techniques [62,67,89,90]. Among these methods, Atomic layer deposition and hydrothermal growth allow depositing ZnO nanostructues at low temperatures [66,89,92] simplifying the actual problem of miniaturization and integration with testing systems.…”

Section: New Targets and Integrates Systemsmentioning

confidence: 99%

“…Nowadays, the most developed and used biosensor platforms are electrical [29,32,33,37,42,46,47,56,87] and electrochemical [16,30,31,38,39,55,88,90,[92][93][94]. Electrical in particular are based on their Field Effect Transistor (FET) platforms demonstrate high level of detection but require additional input of lithography and nanotechnology, what makes these devices more complex and expensive.…”

Section: Introductionmentioning

confidence: 99%

“…Regarding to a progress in nanotechnology and material science, new technological methods have been developed to fabricate nanostructured ZnO templates with high surface area and advanced properties for biosensors. Nanostructured ZnO films have been widely used as template in electrochemical biosensors before demonstrating good sensitivity and low detection limit [30,39,55,88,90,[92][93][94], while ZnO nanowires, nanorods etc. have been widely used recently as the sensing element in FET biosensors [29,33,87].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Optical biosensors based on ZnO nanostructures: advantages and perspectives. A review

Tereshchenko

Bechelany

Viter

et al. 2016

Sensors and Actuators B: Chemical

274

206

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Section: Direct Immobilization Of Biomolecules On Top Of Zno Nanostrumentioning

confidence: 99%

Section: Novel Trends In Zno Biosensor Platformsmentioning

confidence: 99%

Section: New Targets and Integrates Systemsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optical biosensors based on ZnO nanostructures: advantages and perspectives. A review

Tereshchenko

Bechelany

Viter

et al. 2016

Sensors and Actuators B: Chemical

274

206

View full text Add to dashboard Cite

Advanced Point‐of‐Care Testing Technologies for Human Acute Respiratory Virus Detection

et al. 2021

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system leading to respiratory tract infections (respiratory viruses, RVs). These diseases have the highest morbidity and fatality rates among acute infectious diseases and have caused a series of pandemics throughout human history. The first recorded RV occurred in 1200 BC, and subsequent major RVs have included the 1918 influenza virus, [1] severe acute respiratory syndrome coronavirus (SARS-CoV-1), [2][3][4][5] 2009 swine flu (H1N1), [6] Middle East respiratory syndrome (MERS) coronavirus, [7,8] and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [9,10] which together have cost billions of lives (Figure 1). [11,12] The epidemics mentioned above impose a significant burden on healthcare systems and the global economy. [13,14] The recurrence of RV epidemics could result from their ubiquitous transmission routes, including direct transmission by sneezing, airborne/aerosol transmission by droplets from infected persons, and transmission by hand-to-eye/nose/mouth contact spreading RVs potentially from contaminated surfaces (handles, elevators, commonly used shared areas, and shopping bags) to an uninfected person. [15][16][17] The major RV types are influenza virus, coronavirus (CoV), adenovirus, respiratory syncytial virus (RSV), rhinovirus,The ever-growing global threats to human life caused by the human acute respiratory virus (RV) infections have cost billions of lives, created a significant economic burden, and shaped society for centuries. The timely response to emerging RVs could save human lives and reduce the medical care burden. The development of RV detection technologies is essential for potentially preventing RV pandemic and epidemics. However, commonly used detection technologies lack sensitivity, specificity, and speed, thus often failing to provide the rapid turnaround times. To address this problem, new technologies are devised to address the performance inadequacies of the traditional methods. These emerging technologies offer improvements in convenience, speed, flexibility, and portability of point-of-care test (POCT). Herein, recent developments in POCT are comprehensively reviewed for eight typical acute respiratory viruses. This review discusses the challenges and opportunities of various recognition and detection strategies and discusses these according to their detection principles, including nucleic acid amplification, optical POCT, electrochemistry, lateral flow assays, microfluidics, enzyme-linked immunosorbent assays, and microarrays. The importance of limits of detection, throughput, portability, and specificity when testing clinical samples in resource-limited settings is emphasized. Finally, the evaluation of commercial POCT kits for both essential RV diagnosis and clinical-oriented practices is included.

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Interaction Study of Anti‐E. coli Immobilization on 1DZnO at Nanoscale for Optical Biosensing Application

Salinas

Galdámez‐Martínez

Tolibia

et al. 2023

Adv Materials Inter

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Developing low‐cost biosensing platforms for robust detection response and sensitivity at low concentrations is of great interest. This work reports synthesizing 1D ZnO nanostructured materials (1DZnO) with controllable properties utilizing a metal catalyst‐assisted vapor phase growth technique (VLS). The obtained materials are functionalized with (3‐aminopropyl) trimetoxysilane (APTMS) and immobilized with anti‐Escherichia coli enteropathogenic (EPEC) antibodies. Characterization results show changes in the optical and structural properties of 1DZnO that are correlated with the biofunctionalization methodologies. Further, the biofunctionalization process is assessed on 1DZnO surface platforms to obtain acceptable antibody immobilization efficiencies (52%, 96%, and 100%) using a low‐concentration antibody solution (30 µg ml−1). Special techniques such as focused ion beam micromachining and scanning tunneling electron microscopy are proposed to appreciate the semiconductor biofunctionalization layer around 1DZnO and explain the physics of the interaction process. It is found that morphology obtained from distinct synthesis methods, solvents, and functionalization agents can generate functional groups for biomolecule attachment. Remarkably, it is demonstrated that biofunctionalization on 1DZnO takes place all over a single nanostructure. This work presents a proof‐of‐concept focused on generating pathogen sensing platforms using 1DznO semiconducting materials, providing new insights into bio‐analytes interaction with structures at the nanoscale.

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A multi-virus detectable microfluidic electrochemical immunosensor for simultaneous detection of H1N1, H5N1, and H7N9 virus using ZnO nanorods for sensitivity enhancement

Cited by 108 publications

References 26 publications

Optical biosensors based on ZnO nanostructures: advantages and perspectives. A review

Optical biosensors based on ZnO nanostructures: advantages and perspectives. A review

Advanced Point‐of‐Care Testing Technologies for Human Acute Respiratory Virus Detection

Interaction Study of Anti‐E. coli Immobilization on 1DZnO at Nanoscale for Optical Biosensing Application

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