A multi-tissue and -breed catalogue of chromatin conformations and their implications in gene regulation in pigs
Hongwei Yin,
Qianyi Zhao,
Liu Yang
et al.
Abstract:Background
Topologically associating domains (TADs) are functional units that organize chromosomes into 3D structures of interacting chromatin, and play a crucial role in regulating gene expression by constraining enhancer-promoter contacts. Evidence suggests that deletion of TAD boundaries can lead to aberrant expression of neighboring genes. In our study, we analyzed high-throughput chromatin conformation capture (Hi-C) datasets from publicly available sources, integrating 71 datasets across five tissues in… Show more
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