Summarytive dose theraw might be beneficial in the treatment of RDS, Surface active aerosols were produced from aqueous dispersions of mixed lipids (CLL), extracted fnnn bovine lung lavage. Particle size distributioas were measured as a funetion of humMity far two types of aerosol generators: ultrrrsoaif and jet. Lipid dispersions betore aerosolhation were prepared by sonication in an ice bath and by mechanical vortexing. Over a range of bigh huaddity greater than 60-70%, ultrasonic nebulization gave CLL lerosds with mass median aerodynamic diameters (MMAD) of 1.4 * 0.1 pm, compatible with predicted alveolar deposition fractions of 03-0.3 according to current deposition models. For humidities of 30-%%, jet nebulization gave MMAD values of 0.4-03 pm, rrhicb have lower predicted alveolar deposition. The surface pressuretime (n -t) adsomtion characteristics at 35 * 2OC of CLL dispe&ions &epari initially by vortexing or sonication were not significantly affected by ultrasonic nebulization over a 1-2 h time period. In addition, the dynamic surface tension lowering of both W s of CLL dispersion was not affected by ultrasonic nebulizrrtioo (minimum surface tension