PurposeThe focus of industrial cluster innovation lies in the cooperation between enterprises and universities/scientific research institutes to make a theoretical breakthrough in the system and mechanism of industrial cluster network. Under the theoretical framework of cluster network, industrial structure can be optimized and upgraded, and enterprise benefit can be improved. Facing the increasing proliferation and multi-structured enterprise data, how to obtain potential and high-quality innovation features will determine the ability of industrial cluster network innovation, as well as the paper aims to discuss these issues.Design/methodology/approachBased on complex network theory and machine learning method, this paper constructs the structure of “three-layer coupling network” (TLCN), predicts the innovation features of industrial clusters and focuses on the theoretical basis of industrial cluster network innovation model. This paper comprehensively uses intelligent information processing technologies such as network parameters and neural network to predict and analyze the industrial cluster data.FindingsFrom the analysis of the experimental results, the authors obtain five innovative features (policy strength, cooperation, research and development investment, centrality and geographical position) that help to improve the ability of industrial clusters, and give corresponding optimization strategy suggestions according to the result analysis.Originality/valueBuilding a TLCN structure of industrial clusters. Exploring the innovation features of industrial clusters. Establishing the analysis paradigm of machine learning method to predict the innovation features of industrial clusters.