A Multi-Modal Implantable CMOS Imaging Device with Two-Color Light Source for Intrinsic Signal Detection in a Brain

Haruta, Makito; Sunaga, Yoshinori; Yamaguchi, Takumi; Takehara, Hiroaki; Noda, Toshihiko; Sasagawa, K.; Tokuda, Takashi; Ohta, Jun

doi:10.7567/ssdm.2014.d-7-3

Cited by 1 publication

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“…[13][14][15][16][17][18][19] Although the CMOS image sensors are somewhat invasive, brain functional imaging can be performed even under freely moving conditions. Indeed, we have achieved the blood flow response imaging of rats [20][21][22] and the fluorescence imaging of the hippocampus of mice [23][24][25] using our implantable CMOS imaging devices.…”

Section: Introductionmentioning

confidence: 99%

Implantable imaging device for brain functional imaging system using flavoprotein fluorescence

Sunaga

Yamaura

Haruta

et al. 2016

Jpn. J. Appl. Phys.

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The autofluorescence of mitochondrial flavoprotein is very useful for functional brain imaging because the fluorescence intensity of flavoprotein changes as per neural activities. In this study, we developed an implantable imaging device for green fluorescence imaging and detected fluorescence changes of flavoprotein associated with visual stimulation using the device. We examined the device performance using anesthetized mice. We set the device on the visual cortex and measured fluorescence changes of flavoprotein in response to visual stimulation. A full-field sinusoidal grating with a vertical orientation was used for applying to activate the visual cortex. We successfully observed visually evoked fluorescence changes in the mouse visual cortex using our implantable device. This result suggests that we can observe the fluorescence changes of flavoprotein associated with visual stimulation in a freely moving mouse by using this technology.

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