A multi-functional picolinohydrazide-based chemosensor for colorimetric detection of iron and dual responsive detection of hypochlorite

Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

“…77–79 Higher levels of Zn and Al in the brain influence the disease pathology and their measurements in the brain are a potential biomarker. 74,84–88 There are many chemical tools developed to selectively detect and image metal ions that could be exploited to assess the metal ion levels in the AD brain for diagnosis. 78–88 We have developed selective fluorescence sensors for the detection of copper and iron, and evaluated in vitro and cell models.…”

“…74,84–88 There are many chemical tools developed to selectively detect and image metal ions that could be exploited to assess the metal ion levels in the AD brain for diagnosis. 78–88 We have developed selective fluorescence sensors for the detection of copper and iron, and evaluated in vitro and cell models. 78,79,82,84 A dual response colorimetric and fluorescence sensor for the differential detection of Zn and Al and fluorescence sensors for Zn and Al were developed.…”

“…86,87 They recently developed a colorimetric and fluorescent dual responsive chemical probe for bioimaging of Fe in cells. 88 The reported chemical probes are demonstrated for in vitro and in vivo applications. These probes need to be explored for their utility in the diagnosis of AD by the detection and imaging of biometals in the clinical context.…”

A nitrobenzodioxazole‐based water‐soluble chemosensor for colorimetric quantification of aqueous hypochlorite

“…[25][26][27] In recent years, some of the colorimetric chemosensors detecting ClO À have been reported. [28][29][30][31][32][33][34] However, most of the reported chemosensors are not soluble in water 30 and thus, do work in organic media. [31][32][33][34] Even if the chemosensors operate in water, they have poor limits of detection 28,35,36 or complicated synthetic procedures.…”

A novel quinoline derivative as a highly selective and sensitive fluorescent sensor for Fe3+ detection

“…Fe 3+ is the fourth most abundant element in the environment and is the backbone of industrial development. [1][2][3] Meanwhile Fe 3+ is one of the necessary ions for life, and is involved in many cellular biochemical processes. The deciency or excess of Fe 3+ will lead to a series of diseases, for example, Fenton reaction may take place in the presence of excess Fe 3+ in cells, and the generated reactive oxygen species (ROS) from Fenton reaction are able to induce neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease.…”