A multi-evaluating strategy for Weikangling capsules: Chemical profiling, fingerprinting combined with quantitative analysis, quantity transfer, and dissolution curve

Liu, Feng; Ding, Haoran; Wang, Mengyue; Li, Xiaobo

doi:10.1016/j.jpba.2021.114347

Cited by 11 publications

(5 citation statements)

References 37 publications

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“…Militarine is all in addition to significant associations with the brain, lungs, liver, intestine, stomach, and other organs. Through direct and/or indirect ways of biotransformation, Militarine exerts its pharmacological effects (such as neuroprotection [ 5 ], improvement of learning and memory [ 30 ], ameliorative effects on cognitive impairment, anti-shock effects [ 4 ], preservation of lung function [ 24 ] and treatment in peptic ulcer [ 26 , 27 ]) on the host [ 5 ] ( Fig. 3 and Table 1 ).…”

Section: Structure-activity Relationship Of Militarinementioning

confidence: 99%

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Jia,

Li,

et al. 2024

Heliyon

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Section: Structure-activity Relationship Of Militarinementioning

confidence: 99%

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Jia,

Li,

et al. 2024

Heliyon

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“…Notably, Zhao et al analysed the content changes of components in the production process of Shengmai injection, 7 while Liu et al investigated the variations in the content of five components during the production of Weikangling capsules. 8 Ding et al conducted a study on the changes in the content of five components in Jizhi syrup. 9 These studies primarily used high-performance liquid chromatography (HPLC) for qualitative and quantitative analysis of the components involved in the process.…”

Section: Introductionmentioning

confidence: 99%

“…Only a few researchers have conducted analyses of the changes in component content throughout the production process. Notably, Zhao et al analysed the content changes of components in the production process of Shengmai injection, 7 while Liu et al investigated the variations in the content of five components during the production of Weikangling capsules 8 . Ding et al conducted a study on the changes in the content of five components in Jizhi syrup 9 .…”

Section: Introductionmentioning

confidence: 99%

Characterisation and critical processes identification for production of herbal preparations using ¹H‐NMR and chemometrics: A case study of Trichosanthis Pericarpium injection

Yang,

Lu,

Dong

et al. 2024

Phytochemical Analysis

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IntroductionHerbal preparations are extensively utilised for the treatment of diseases in Asian countries. However, the variations in origin, climate, and production processes can lead to inconsistencies in the quality of herbal preparations. Existing quality control methods only target a few components in the finished product but ignore the control in the pharmaceutical process. Therefore, this study intends to develop a comprehensive component analysis method for intermediates in the pharmaceutical process to reveal the change patterns of substances and deepen the process understanding.ObjectiveThis study aims to develop a rapid and comprehensive process characterisation and critical process identification method for herbal preparations.MethodsSix batches of Trichosanthis Pericarpium injection (TPI) intermediates were collected from the production process. Proton nuclear magnetic resonance (1H‐NMR) spectra were acquired for qualitative and quantitative analysis of the se intermediates. Subsequently, chemometrics were used to identify critical processes and potential chemical markers.ResultsA total of 39 components in intermediates were identified, and the transfer of 25 components during the production process was investigated. Column chromatography was determined as the critical process. Nine components were identified as chemical markers.ConclusionThe application of 1H‐NMR facilitated a comprehensive reflection of the chemical composition information of process intermediates, enabling investigations into the transfer of multi‐component substances and accurate identification of critical processes and chemical markers.

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“…e chromatographic fingerprint in particular is significant for the evaluation of traditional Chinese medicine, which can better reflect the overall chemical composition of traditional Chinese medicine and is widely used [14][15][16][17]. Li and Chen [18] have established the chromatographic fingerprint of Acacia catechu by HPLC.…”

Section: Introductionmentioning

confidence: 99%

Quality Evaluation of Market Acacia catechu by Fingerprint-Chemical Pattern Recognition

Gao

Meng

et al. 2022

Journal of Chemistry

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Acacia catechu (L.f.) Willd, a leguminous plant, is included in the 2020 edition of the Chinese Pharmacopoeia and is mainly used to treat eczema, mouth ulcers, diarrhea, bruising, and traumatic hemorrhage. However, there are imported and domestic Acacia catechu samples available in China, and their quality and price are very different, which seriously affects the safety and stability of their clinical application. Importantly, there is no simple and effective method for identifying or classifying grades of Acacia catechu. In this study, 47 batches of commercial Acacia catechu were used for identifying or classifying grades of Acacia catechu using high performance liquid chromatography (HPLC) combined with chemometric analysis. Firstly, gradient elution was adopted with 0.05% phosphoric acid water (A)-methanol (B) as the mobile phase to establish chromatographic conditions. The HPLC chromatograms of 47 batches of Acacia catechu samples were analyzed by the “Similarity Evaluation System for Chromatographic Fingerprint of TCM” software (version 2012A). The common peaks of Acacia catechu were identified to evaluate the similarity. Based on the determination results of fingerprint chromatographic peak area, the quality of the collected Acacia catechu was evaluated by chemometric methods such as CA, PCA, and OPLS-DA. The results showed that the collected Acacia catechu samples were significantly divided into three categories. The first-class samples were all imported Acacia catechu except S9 sample, which was domestic Acacia catechu; the second-class samples were partly domestic Acacia catechu and partly imported Acacia catechu; and the third-class samples were all domestic Acacia catechu. Moreover, OPLS-DA of 47 batches of samples showed that the contents of catechin and the total contents of catechin and epicatechin could be used as key indicators for assessing the quality of Acacia catechu. The developed HPLC fingerprint and quantitative analysis method of multi-indicator components can be used for classification and quality evaluation of market Acacia catechu, which has a significant reference value for developing Acacia catechu grade quality standards.

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A multi-evaluating strategy for Weikangling capsules: Chemical profiling, fingerprinting combined with quantitative analysis, quantity transfer, and dissolution curve

Cited by 11 publications

References 37 publications

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Characterisation and critical processes identification for production of herbal preparations using ¹H‐NMR and chemometrics: A case study of Trichosanthis Pericarpium injection

Quality Evaluation of Market Acacia catechu by Fingerprint-Chemical Pattern Recognition

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A multi-evaluating strategy for Weikangling capsules: Chemical profiling, fingerprinting combined with quantitative analysis, quantity transfer, and dissolution curve

Cited by 11 publications

References 37 publications

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

Characterisation and critical processes identification for production of herbal preparations using 1H‐NMR and chemometrics: A case study of Trichosanthis Pericarpium injection

Quality Evaluation of Market Acacia catechu by Fingerprint-Chemical Pattern Recognition

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Product

Resources

About

Characterisation and critical processes identification for production of herbal preparations using ¹H‐NMR and chemometrics: A case study of Trichosanthis Pericarpium injection