A Multi-Domain Continuum Model of Electrical Stimulation of Healthy and Degenerate Retina

Abstract

ORIGINALITY STATEMENT'I hereby declare that this submission is my own work and to the best of my knowledge it contains no materials previously published or written by another person, or substantial proportions of material which have been accepted for the award of any other degree or diploma at UNSW or any other educational institution, except where due acknowledgement is made in the thesis. Any contribution made to the research by others, with whom I have worked at UNSW or elsewhere, is explicitly acknowledged in the thesis. I also declare that the intellectual content of this thesis is the product of my own work, except to the extent that assistance from others in the project's design and conception or in style, presentation and linguistic expression is acknowledged.'

A Multi-Scale Simulation of Retinal Physiology

“…This model has since been further developed, in various directions, for various purposes, such as handling different electrode stimulation techniques, using finite element implementation, and incorporating more details of the retina [28,72,73,27,57,1,4]. Numerous studies have been conducted based on the various versions of this model and have largely been concerned with visual prosthetics and/or electrical stimulation of the retina [2,58,59,3,5]. Given the scope of their work, the model proposed by Dokos et al does not accurately describe the entire geometry of the retina and makes no attempt to model the entirety of the vitreous chamber.…”

“…A dissimilar multi-domain model of the retina, based on Dokos et al, has been proposed [4]. The multiple domains in that model represent the different compartments of the retinal ganglion cells, such as the dendrites, soma and axon, rather than different cell-types [4,3,5].…”