Oozes are the most widespread deep-sea sediment in the global ocean, but very little is known about how changes in their physical properties impact slope stability and related geohazards. Characterisation of the conditions that prime ooze rich slides has been hindered, as physical properties of sediments are modified by the effects of mass wasting. We here use 3D seismic reflection, geochemical, and petrophysical data acquired both within and adjacent to 13 large (up to c. 6330 km2 in area) submarine slides on the Exmouth Plateau, NW Shelf, Australia, to investigate how the pre-slide physical properties of oozes control slope failure and slide emplacement. Our integrated dataset allows us to detect potential slide surfaces within ooze successions; a crucial advance for improved submarine geohazard assessment. Moreover, we demonstrate that the interplay of tectonics, ocean current activity, and silica diagenesis can prime multiple slides on very low gradient slopes in tropical, oceanic basins. We argue that the diagenesis of silica-rich sediments must be accounted for in future submarine slope stability assessments.