A Multi‐crosslinking Nanocapsule‐Based Serial‐Stimuli‐Responsive Leakage‐Free Drug‐Delivery System In Vitro

Liu, Yazhou; Shen, Tao; Gao, Congcong; El-Ali, H. A. Abdulhadi; Gao, Na; Yang, Cheng; Zhang, Rubo; Jing, Jing

doi:10.1002/chem.201903145

Cited by 3 publications

(3 citation statements)

References 52 publications

(106 reference statements)

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“…This result suggested that after the NPs reached the tumor region, the encapsulated DTX can be released quickly since the tumor microenvironment is known to be mildly acidic . In addition, as shown in Figure i, for the DTX-loaded Zein/CSP NPs without GTP/Fe III coating, the DTX releases were almost identical under different pH conditions, which demonstrated that such pH-responsiveness was mainly due to the presence of the GTP/Fe III network, since there were references reporting that the coordination complex tends to disassemble under acidic environment …”

Section: Results and Discussionmentioning

confidence: 76%

“…41 In addition, as shown in Figure 1i, for the DTX-loaded Zein/CSP NPs without GTP/Fe III coating, the DTX releases were almost identical under different pH conditions, which demonstrated that such pH-responsiveness was mainly due to the presence of the GTP/Fe III network, since there were references reporting that the coordination complex tends to disassemble under acidic environment. 42 In Vitro Photothermal Effect. As a parameter to reflect the photothermal properties of materials, the photothermal conversion efficiency of NPs was computed using the methods in previous references.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Combined Chemo–Immuno–Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform

Han

Dong

et al. 2022

ACS Appl. Mater. Interfaces

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Tumor metastasis and recurrence are recognized to be the main causes of failure in cancer treatment. To address these issues, an “all in one” and “one for all” nanoplatform was established for combined “chemo–immuno–photothermal” therapy with the expectation to improve the antitumor efficacy. Herein, Docetaxel (DTX, a chemo-agent) and cynomorium songaricum polysaccharide (CSP, an immunomodulator) were loaded into zein nanoparticles coated by a green tea polyphenols/iron coordination complex (GTP/FeIII, a photothermal agent). From the result, the obtained nanoplatform denoted as DTX-loaded Zein/CSP-GTP/FeIII NPs was spherical in morphology with an average particle size of 274 nm, and achieved pH-responsive drug release. Moreover, the nanoplatform exhibited excellent photothermal effect both in vitro and in vivo. It was also observed that the nanoparticles could be effectively up take by tumor cells and inhibited their migration. From the results of the in vivo experiment, this nanoplatform could completely eliminate the primary tumors, prevent tumor relapses on LLC (Lewis lung cancer) tumor models, and significantly inhibit metastasis on 4T1 (murine breast cancer) tumor models. The underlying mechanism was also explored. It was discovered that this nanoplatform could induce a strong ICD effect and promote the release of damage-associated molecular patterns (DAMPs) including CRT, ATP, and HMGB1 by the dying tumor cells. And the CSP could assist the DAMPs in inducing the maturation of dendritic cells (DCs) and facilitate the intratumoral infiltration of T lymphocytes to clear up the residual or disseminated tumor cells. In summary, this study demonstrated that the DTX-loaded Zein/CSP-GTP/FeIII is a promising nanoplatform to completely inhibit tumor metastasis and recurrence.

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Section: Results and Discussionmentioning

confidence: 76%

Section: ■ Results and Discussionmentioning

confidence: 99%

Combined Chemo–Immuno–Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform

Han

Dong

et al. 2022

ACS Appl. Mater. Interfaces

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“…The addition of gallic acid (GA), a polyphenolic compound that can be found in various natural foods and fruits, together with doxorubicin (DOX) in multi-crosslinking nanocapsules increased the cytotoxic effect for HepG2 liver cancer cells [ 161 ]. Results indicated that the systems could minimize side effects and optimize cancer therapeutic efficacy.…”

Section: Application Of Nanotechnology Improving the Efficiency Of Po...mentioning

confidence: 99%

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research.

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Natural polyphenols for drug delivery and tissue engineering construction: A review

Liu,

Shi,

Zhang

et al. 2024

European Journal of Medicinal Chemistry

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A Multi‐crosslinking Nanocapsule‐Based Serial‐Stimuli‐Responsive Leakage‐Free Drug‐Delivery System In Vitro

Cited by 3 publications

References 52 publications

Combined Chemo–Immuno–Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform

Combined Chemo–Immuno–Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Natural polyphenols for drug delivery and tissue engineering construction: A review

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