A multi-component integrated approach for the elimination of schistosomiasis in the People’s Republic of China: design and baseline results of a 4-year cluster-randomised intervention trial

Gray, Darren J.; Li, Yuesheng; Williams, Gail M.; Zhao, Zhongwei; Harn, Donald A.; Li, Shengming; Ren, Man; Feng, Zeng; Guo, Fengying; Guo, Jiao; Zhou, Jie; Dong, Yulan; Li, Yuan; Ross, Allen G.; McManus, Donald P.

doi:10.1016/j.ijpara.2014.05.005

Cited by 43 publications

(41 citation statements)

References 30 publications

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“…In China, schistosomiasis was once endemic in 453 counties of 12 provinces south of the Yangtze River [4–6]. According to the environmental ecosystems and snail habitats, schistosomiasis-endemic regions are classified into three types in China, including marshland and lake regions, plain regions with waterway network, and hilly and mountainous regions [7], and a “infection control-transmission control-transmission interruption-elimination” four-stage roadmap has been developed [8–10]. Since the initiation of the national schistosomiasis control program at early 1950s [11–13], schistosomiasis control has been given a high priority in China [14, 15], and multiple integrated strategies have been proposed according to the epidemiological profile and intensity of transmission, which have resulted in a great success in schistosomiasis control in the country [16].…”

Section: Introductionmentioning

confidence: 99%

An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China

Wang

Zuo

et al. 2017

Infect Dis Poverty

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BackgroundSchistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along the Yangtze River basin.MethodsDuring the period from 2001 through 2015, an integrated environmental improvement of the marshlands was carried out through the implementation of industrial, agricultural and resources development projects in Yizheng County along the Yangtze River. S. japonicum infection in humans, livestock and snails was estimated by serology, stool examination, hatching technique and microscopy during the 15-year study period to evaluate the effect of the integrated environmental improvement on control and elimination of schistosomiasis.ResultsA 0.05% overall rate of S. japonicum infection was observed in snails during the 15-year study period, and no infected snails were detected since 2012. The overall prevalence of S. japonicum infection was 0.09% in humans during the study period, and no human infection was found since 2012. In addition, only 13 bovines were identified with S. japonicum infection in 2003 during the 15-year study period, and since 2004, no infection was found in livestock.ConclusionThe results of the present study demonstrate that the implementation of industrial, agricultural and water resources development projects, not only alters snail habitats in marshland regions, and promotes local economic development, which appears a win-to-win strategy to block the transmission of S. japonicum and accelerate socio-economic development along the Yangtze River.Electronic supplementary materialThe online version of this article (doi:10.1186/s40249-017-0287-1) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China

Wang

Zuo

et al. 2017

Infect Dis Poverty

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“…Although schistosomiasis control in Poyang Lake Region was clearly successful in recent years, the epidemic is still a severe challenge. The epidemic can persist due to the parasite’s complex life-cycle involving many different definitive mammalian hosts besides humans and cattle and an intermediate snail host with grass-related habitats influenced by the constantly changing environment [26]. Based on the analysis above, we concluded that the identification of hotspots of infection risk should become a vital part in future strategies of precise schistosomiasis control.…”

Section: Discussionmentioning

confidence: 99%

Village-based spatio-temporal cluster analysis of the schistosomiasis risk in the Poyang Lake Region, China

Chen

Bergquist²,

Lynn

et al. 2017

Parasites Vectors

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BackgroundThe Poyang Lake Region, one of the major epidemic sites of schistosomiasis in China, remains a severe challenge. To improve our understanding of the current endemic status of schistosomiasis and to better control the transmission of the disease in the Poyang Lake Region, it is important to analyse the clustering pattern of schistosomiasis and detect the hotspots of transmission risk.ResultsBased on annual surveillance data, at the village level in this region from 2009 to 2014, spatial and temporal cluster analyses were conducted to assess the pattern of schistosomiasis infection risk among humans through purely spatial (Local Moran’s I, Kulldorff and Flexible scan statistic) and space-time scan statistics (Kulldorff). A dramatic decline was found in the infection rate during the study period, which was shown to be maintained at a low level. The number of spatial clusters declined over time and were concentrated in counties around Poyang Lake, including Yugan, Yongxiu, Nanchang, Xingzi, Xinjian, De’an as well as Pengze, situated along the Yangtze River and the most serious area found in this study. Space-time analysis revealed that the clustering time frame appeared between 2009 and 2011 and the most likely cluster with the widest range was particularly concentrated in Pengze County.ConclusionsThis study detected areas at high risk for schistosomiasis both in space and time at the village level from 2009 to 2014 in Poyang Lake Region. The high-risk areas are now more concentrated and mainly distributed at the river inflows Poyang Lake and along Yangtze River in Pengze County. It was assumed that the water projects including reservoirs and a recently breached dyke in this area were partly to blame. This study points out that attempts to reduce the negative effects of water projects in China should focus on the Poyang Lake Region.

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“…Therefore, the Dongting Lake district has become the most serious schistosomiasis endemic area in our country Gray et al, 2014).…”

Section: Overview Of the Study Areamentioning

confidence: 99%

The influence of natural factors on the spatio-temporal distribution of Oncomelania hupensis

Cheng

Zhuang

et al. 2016

Acta Tropica

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A multi-component integrated approach for the elimination of schistosomiasis in the People’s Republic of China: design and baseline results of a 4-year cluster-randomised intervention trial

Cited by 43 publications

References 30 publications

An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China

An integrated environmental improvement of marshlands: impact on control and elimination of schistosomiasis in marshland regions along the Yangtze River, China

Village-based spatio-temporal cluster analysis of the schistosomiasis risk in the Poyang Lake Region, China

The influence of natural factors on the spatio-temporal distribution of Oncomelania hupensis

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