A multi-center comparison of dual energy X-ray absorptiometers: In vivo and in vitro soft tissue measurement

Economos, C. D.; Nelson, M. E.; Fiatarone, Ma; Dallal, GE; Heymsfield, S. B.; Wang, J; Yasumara, S; Ma, Ruimei; Vaswani, A.; Russell‐Aulet, Mary; Pierson, R. N.

doi:10.1038/sj.ejcn.1600400

Cited by 37 publications

(27 citation statements)

References 38 publications

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“…Elsewhere, and also using the more recent iDXA model, precision for TBL measurements have also been reported as excellent, with CVs of 0.4% (Rezzi et al, 2009), 0.52% (Faulkner et al, 2006) and 0.55% (Krueger et al, 2006).We also found excellent precision for the measurement of BMC, TBF and %TBF, compared with values reported elsewhere for older models of DXA and in a range of participants (Economos et al, 1997;Figueroa-Colon et al, 1998;Oldroyd et al, 2003). In this study, precision values for body composition parameters are comparable with those reported by studies elsewhere, which have also used the iDXA.…”

Section: Resultssupporting

confidence: 81%

In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults

2010

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In vivo precision for body composition measurements using dual energy X-ray absorptiometry (DXA; GE Lunar iDXA, GE Healthcare, Bucks, UK) was evaluated in 52 men and women, aged 34.8 (s.d. 8.4; range 20.1-50.5) years, body mass index (25.8 kg/m 2 ; range 16.7-42.7 kg/m 2 ). Two consecutive total body scans (with re-positioning) were conducted. Precision was excellent for all measurements, particularly for total body bone mineral content and lean tissue mass (root mean square 0.015 and 0.244 kg; coefficients of variation (CV) 0.6 and 0.5%, respectively). Precision error was CV 0.82% for total fat mass and 0.86% for percentage fat. Precision was better for gynoid (root mean square 0.397 kg; CV 0.96%) than for android fat distribution (root mean square 0.780 kg, CV 2.32%). There was good agreement between consecutive measurements for all measurements (slope (s.e.) 0.993-1.002; all R 2 ¼ 0.99). The Lunar iDXA provided excellent precision for total body composition measurements. Research into the effect of body size on the precision of DXA body fat distribution measurements is required.

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Section: Resultssupporting

confidence: 81%

In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults

2010

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“…DXA was performed at baseline, 8 weeks, and 16 weeks using a Hologic QDR2000 densitometer operating in array mode (Hologic, Waltham, MA, USA; software version 5.64A). This method has been validated against multi-compartmental methods and compared to in-vivo neutron inelastic scattering [8][9][10].…”

Section: Methodsmentioning

confidence: 99%

A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution

Roubenoff

Weiss

McDermott

et al. 1999

AIDS

153

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Objective: Body fat redistribution ('lipodystrophy'), with gain in abdominal and trunk fat, and decline in facial and limb fat, is a newly recognized problem in patients with HIV infection that has been linked to use of HIV-1 protease inhibitors. Increased abdominal fat may predispose these patients to hypertension, diabetes, and coronary artery disease. At this time no effective treatment is available. We examined whether exercise training could reduce trunk fat in men with fat redistribution.Design: Open-label pilot study. Methods:Ten men with increasing abdominal girth participated in a 16 week pilot study of progressive resistance training with an aerobic component. They trained in a community health club three times per week. Total body lean and fat mass, and trunk fat mass, were assessed by dualenergy x-ray absorptiometry (DXA). Results:After 16 weeks of exercise, strength increased for three of the four exercises tested (leg press + 13% [p < 0.02], leg extension + 19% [p < 0.03], seated row + 7% [p < 0.13], chest press + 18% [p < 0.005]). There was a significant decline in total body fat by 1.5 kg (= 2.1 percentage points, p < 0.01); most of the decline in body fat occurred in trunk fat, which decreased by 1.1 kg (p < 0.03). Weight, lean mass (+ 1.1 ± 2.6 kg, p = 0.23), and bone mineral density measured by DXA did not change. No adverse effects were seen from the training. Conclusions:Exercise training may reduce trunk fat mass in HIV-positive men with fat redistribution. Controls trials of this approach are warranted.

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“…To overcome the systematic bias in DXA %fat measurement, we recommend the development of calibration models for DXA group mean %BF estimates in adolescent athletes, even though individual %BF estimates cannot be performed. The applicability of this recommendation to DXA instruments made by other manufacturers or to DXA instruments that use different scans modes and software is not known, though a few studies have shown a lack of interchangeability in DXA systems to assess soft tissue (Paton et al, 1995;Economos et al, 1997;Tothill et al, 1999;Tothill and Hannan, 2000).…”

Section: Validity Of Dual Energy X-ray Absorptiometrymentioning

confidence: 99%

Body fat measurement in adolescent athletes: multicompartment molecular model comparison

et al. 2006

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Objective: To assess the accuracy of air displacement plethysmography (ADP) and dual energy X-ray absorptiometry (DXA) per cent body fat (%BF) estimations in comparison with a reference five-compartment (5C) model used as the reference method. Design: Cross-sectional study. Setting: Outpatient University Laboratory, Lisbon, Portugal. Methods: A total of 32 girls (age: 15.170.3 years) and 46 boys (age: 15.371.2 years) athletes were measured. Body volume was assessed by ADP; bone mineral content was assessed by DXA; and total-body water was assessed by deuterium dilution. Statistical analyses included examination of the coefficient of correlation (r), standard error of estimation (s.e.e.), slope, intercept, and pure error (p.e.) and the agreement between models. Results: For boys and girls, differences between the 5C model and ADP %BF were 0.2 and 1.7% (r ¼ 0.86 and 0.98, s.e.e. ¼ 2.50 and 1.55%, p.e. ¼ 2.77 and 2.23%), respectively. Differences between the 5C model and DXA %BF were -1.0 and -3.7% (r ¼ 0.85 and 0.91, s.e.e. ¼ 2.60 and 2.91%, p.e. ¼ 2.90 and 4.66%), for boys and girls, respectively. For girls, regression between ADP and DXA against the reference method did not differ from the line of identity (P40.05) while for boys differences were found (Po0.05). Dual energy X-ray absorptiometry overestimated %BF, particularly in girls. For both genders, large limits of agreement were found between the reference method and both techniques, with the exception of ADP in female athletes. Conclusion: We conclude that the two techniques were not precise for individual %BF prediction, though ADP revealed better agreement for girls. However, considering all performance criteria for the mean group, our analysis highlights ADP as a valid and nonbiased tool for the evaluation of body composition in adolescent athletes.

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A multi-center comparison of dual energy X-ray absorptiometers: In vivo and in vitro soft tissue measurement

Cited by 37 publications

References 38 publications

In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults

In vivo precision of the GE Lunar iDXA densitometer for the measurement of total body composition and fat distribution in adults

A pilot study of exercise training to reduce trunk fat in adults with HIV-associated fat redistribution

Body fat measurement in adolescent athletes: multicompartment molecular model comparison

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