A mouse model of depression induced by repeated corticosterone injections

Zhao, Yunan; Ma, Richard; Shen, Jia; Su, Hui; Xing, Dongming; Du, Lijun

doi:10.1016/j.ejphar.2007.12.005

Cited by 264 publications

(174 citation statements)

References 56 publications

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“…1 Four-week CORT injections were also found in this study to greatly increase serum CORT levels and depression-like behavior in male mice both in the FST and the TST (P<0.01). This is similar to the study of Zhao et al (2008) and further confirms that long-term exposure to high CORT levels could cause depression-like behavior in rodents.…”

Section: Behavsupporting

confidence: 77%

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Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice

Zhang

Zhao

Wang

et al. 2015

J. Zhejiang Univ. Sci. B

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Section: Behavsupporting

confidence: 77%

“…The CORT group was conducted as described by Zhao et al (2008). The animals in the CORT group received subcutaneous CORT injection (20 mg/kg) once per day (5 ml/kg) at random times during the light phase.…”

Section: Cort Administrationmentioning

confidence: 99%

Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice

Zhang

Zhao

Wang

et al. 2015

J. Zhejiang Univ. Sci. B

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“…Repeated s.c. injection of corticosterone can mimic stress-induced elevation of corticosterone levels and induces depression in animal models (15). To investigate the effect of glucocorticoids on p53 in vivo, p53 +/+ C57BL6/J mice were injected with corticosterone (20 mg/kg) for 1 wk followed by IR (4 Gy).…”

Section: Glucocorticoids Decrease P53 Protein Levels and Function In mentioning

confidence: 99%

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

Feng

Liu²,

Zhang³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

167

138

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Epidemiological studies strongly suggest that chronic psychological stress promotes tumorigenesis. However, its direct link in vivo and the underlying mechanisms that cause this remain unclear. This study provides direct evidence that chronic stress promotes tumorigenesis in vivo; chronic restraint, a well-established mouse model to induce chronic stress, greatly promotes ionizing radiation (IR)-induced tumorigenesis in p53 +/− mice. The tumor suppressor protein p53 plays a central role in tumor prevention. Loss or attenuation of p53 function contriubutes greatly to tumorigenesis. We found that chronic restraint decreases the levels and function of p53 in mice, and furthermore, promotes the growth of human xenograft tumors in a largely p53-dependent manner. Our results show that glucocorticoids elevated during chronic restraint mediate the effect of chronic restraint on p53 through the induction of serum-and glucocorticoid-induced protein kinase (SGK1), which in turn increases MDM2 activity and decreases p53 function. Taken together, this study demonstrates that chronic stress promotes tumorigenesis in mice, and the attenuation of p53 function is an important part of the underlying mechanism, which can be mediated by glucocortcoids elevated during chronic restraint.

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“…There are several reports that chronic exposure to restraint stress for 15 days (2 hrs daily) leads to the induction of depressive symptoms in rat [32,33]. Chronic injection of corticosterone at an elevated dose has been used in development of stress induced depression model in number of anti depressant studies [34]. Previous studies in hypoxic models also have reported the induction of anxiety-like behaviors in humans [35,36].…”

mentioning

confidence: 99%

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

Baitharu¹,

Jain²,

Deep³

et al. 2013

JBBS

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Chronic exposure to hypobaric hypoxia (HH) causes memory impairment and prolonged state of mental confusion. However, effect of high altitude exposure on mood state and its underlying mechanisms have been poorly studied. Present study was undertaken to investigate the mood state alteration following chronic exposure to HH. Male Sprague Dawley rats were divided into five groups and exposed to hypoxia for 3, 7, 14 and 21 days in an animal decompression chamber at an altitude of 25,000ft. Anxiety-and depression-like behaviors were assessed by using various mazes along with changes in serotonin and glutamate level. Our study revealed a decrease in exploratory, grooming and rearing behavior in open field test following initial exposure to HH for 7 days without affecting the locomotory behavior. Initial exposure to HH-decreased time spent in open arm of elevated plus maze indicating induction of anxiety-like behavior which normalized on prolonged hypoxic exposure for 21 days. Hypoxic exposure for 7 days induced anhedonia and increased despair behavior in rat while there was steady improvement in these behaviors when exposed for 21 days. Decrease in serotonin level was noted in hippocampus along with elevated corticosterone and glutamate level which gradually decreased on prolonged exposure to HH. These findings suggest that initial exposure to HH increases transient anxiety-like behavior in rats followed by gradual improvement in mood state on prolonged exposure. Further, the study also indicates the involvement of serotonergic system in mood state alteration at high altitude following chronic exposure and reoxygenation.

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A mouse model of depression induced by repeated corticosterone injections

Cited by 264 publications

References 56 publications

Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice

Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

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