A mouse homoeo box gene is expressed during embryogenesis and in adult kidney

Jackson, Ian J.; Schofield, Paul N.; Hogan, Brigid L.M.

doi:10.1038/317745a0

Cited by 116 publications

(64 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This stage of embryogenesis has been studied most extensively for homeo box gene expression, because in many cases it is the time when maximal transcript levels are seen by Northern or RNase protection analysis of total embryo RNA (Colberg-Poley et al 1985;Jackson et al 1985;Awgulewitsch et al 1986;Joyner and Martin 1987;Rubin et al 1987). By this time, all the major systems of the body have been established.…”

Section: Embryos About Two-thirds Through Gestation (125 Days Pc; Smentioning

confidence: 99%

“…However, RNase protection or Northern analysis, using RNA pooled from a large number of embryos, has revealed very low levels of Hox-2.1 and Hox-1.3 RNA at 7.5 days p.c. (Jackson et al 1985;Odenwald et al 1987). Improvements in sensi-tivity for in situ hybridization and use of antibody probes would clearly facilitate analysis of these genes in presomite embryos.…”

Section: Minal-j)mentioning

confidence: 99%

See 1 more Smart Citation

Expression of homeo box genes during mouse development: a review.

Holland¹,

Hogan²

1988

Genes Dev.

314

134

View full text Add to dashboard Cite

Section: Embryos About Two-thirds Through Gestation (125 Days Pc; Smentioning

confidence: 99%

Section: Minal-j)mentioning

confidence: 99%

Expression of homeo box genes during mouse development: a review.

Holland¹,

Hogan²

1988

Genes Dev.

314

134

View full text Add to dashboard Cite

“…About half of the 38 known Hox genes have been shown to be expressed in adult human (37,38) and mouse (39,40) (54,55). Figure 1 summarizes the available data for lung expression.…”

Section: Hox Gene Expression In the Lungmentioning

confidence: 99%

Hox genes in the lung.

Kappen

1996

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Hox genes are a specific subgroup of homeobox containing genes that are characterized by their structural and functional homology to homeotic genes of the fruit fly Drosophila (1). These genes play important roles in pattern formation along the anterior-posterior axis in the developing embryo in both invertebrates and vertebrates (2). The proteins encoded by Hox genes contain the DNA-binding homeodomain (3), and are therefore believed to act as transcription factors that regulate the expression of other genes during morphogenesis (4, 5). More than 100 of other genes have been identified in mammals that encode homeodomain proteins (6, 7) of which the Hox genes are the best characterized. A growing number of animals with genetically induced aberrant Hox gene expression is providing insight into the crucial function of Hox genes in axial patterning; it is also becoming clear that Hox genes are important in the development of internal organs and the differentiation of tissues.The development of the lung starts out from protrusions of the primitive gut, the lung buds (8). Elongation and branching then leads to the formation of the trachea and bronchi and progressive branching elaborates the distal alveoli (9). The proximal-distal orientation of these distinct structures suggests that they could be specified by mechanisms paralleling those that govern anterior-posterior (rostral-caudal) axial specification. The inner surface of the lung is derived from endodermal cells that differentiate into epithelial cells under the influence of the surrounding mesenchymal cells which are of mesodermal origin (reviewed in (10). It is believed that interactions with the mesenchyme are important for epithelial cell differentiation and function. In short, lung development is characterized by two phases, the early specification of the proximal-distal axis and later events of tissue differentiation. As I will present here, there is increasing evidence that Hox genes are involved both in regional specification and cell differentiation in lung development. The genomic organization of vertebrate Hox genesis characterized by their arrangement in chromosomal clusters (11). Figure 1 shows schematically that highly similar genes (paralogs) occupy corresponding positions on different clusters. Intriguingly, the position of genes within a cluster is correlated to their order of expression along the anterior-posterior (rostral-caudal) axis (12). In addition, the genes located towards the 5′ end of the clusters have been shown to be expressed in developing limbs in anterior-posterior (thumb-pinkie) and proximal-distal direction (13). The overlapping but distinct expression patterns have been taken to suggest that a combinatorial code of Hox gene expression specifies the subsequent development of a given body region (14).

show abstract

“…Expression of the Hox-1.3 gene in adult animals is not surprising because many mammalian homeobox genes are expressed in adult tissues. For example, every mouse homeobox gene whose expression has been examined in detail in adult tissues has been found to be ex- pressed in both embryonic and adult tissues (Awgulewitsch et al 1986;Colberg-Poley et al 1985;Jackson et al 1985;Rubin et al 1986;Wogelmuth et al 1986). …”

Section: Discussionmentioning

confidence: 99%

Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands

Shaw

Zhang

Russo

et al. 2003

J Histochem Cytochem.

View full text Add to dashboard Cite

S U M M A R Y Homeobox-containing (Hox) genes play important roles in development, particularly in the development of neurons and sensory organs, and in specification of body plan. The Hmx gene family is a new class of homeobox-containing genes defined by a conserved homeobox region and a characteristic pattern of expression in the central nervous system that is more rostral than that of the Hox genes. To date, three closely related members of the Hmx family, Hmx1, Hmx2, and Hmx3, have been described. All three Hmx genes are expressed in the craniofacial region of developing embryos. Here we show, for the first time, the expression of the transcription factor Hmx3 in postnatally developing salivary glands. Hmx3 protein is expressed in a cell type-specific manner in rat salivary glands. Hmx3 is present in both the nuclei and cytoplasm of specific groups of duct cells of the submandibular, parotid, and sublingual glands. Hmx3 expression increases during postnatal development of the submandibular gland. The duct cells show increasing concentrations of Hmx3 protein with progressive development of the submandibular gland. In contrast, the acinar cells of the three salivary glands do not exhibit detectable levels of Hmx3 protein.

show abstract

A mouse homoeo box gene is expressed during embryogenesis and in adult kidney

Cited by 116 publications

References 18 publications

Expression of homeo box genes during mouse development: a review.

Expression of homeo box genes during mouse development: a review.

Hox genes in the lung.

Homeobox Protein, Hmx3, in Postnatally Developing Rat Submandibular Glands

Contact Info

Product

Resources

About