A mouse homeo box - containing gene maps near a developmental mutation

Hill, R.E.; Hall, Ashley; Sime, C.; Hastie, N.D.

doi:10.1159/000132366

Cited by 17 publications

(7 citation statements)

References 6 publications

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“…match cleavage technique was used to look for any base Analysis of Gli2 Coding Sequence changes (Condie et al, 1993). An anomalous fragment In the absence of gross genomic abnormalities and was observed in fragment 1, and sequence analysis of PCR products identified a silent base change in both changes in expression levels of Gli2 in Dh, we analyzed et al, 1994), and c (Hill et al, 1987).…”

Section: Fig 1-continuedmentioning

confidence: 99%

Cloning and Sequencing of the MouseGli2Gene: Localization to theDominant hemimeliaCritical Region

et al. 1997

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Section: Fig 1-continuedmentioning

confidence: 99%

Cloning and Sequencing of the MouseGli2Gene: Localization to theDominant hemimeliaCritical Region

et al. 1997

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“…In the mouse, this complex is located on chromosome 2 [27]. However, the mouse En-2 gene is located on chromosome 1 [28], and the long arm of human chromosome 2 corresponds to mouse chromosomes 1 or 2, as indicated by comparative genome mapping [18,19]. In fact, human EN-1 is located on chromosome 2 [21].…”

Section: Supping Of the Heap Gbx2 And En-1 Genesmentioning

confidence: 99%

The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans

et al. 1993

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The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans Received 5 October 1993Two newly identified human homeobox-containing genes, GBXI and GBX2, are closely related genes, as are members of the other homeobox genes, EN-I and EN-2. GBXI and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-I was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution.

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“…No crossovers were detected between Tgfb-2 and Hlx, giving 95% confidence that they lie within 1.6 cM (probably within a few megabases). The placement of At-3, Spna-1, and Tgfb-2 relative to other chromosome 1 markers on the interspecific and composite intraspecific backcross maps (see Dickinson et al 1990) places Hlx well below the loci for the En-1 (Hill et al 1987;Joyner and Martin 1987) and Oct-1 (Hsieh et al 1990) homeo box loci. Interspecific backcross analysis on the same panel maps Copeland, and N.A.…”

Section: N E W Homeo Box Locus On the Distal Portion Of Mouse Chromosmentioning

confidence: 99%

Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.

Allen¹,

Lints²,

Jenkins³

et al. 1991

Genes Dev.

103

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We describe here a new murine homeo box gene, denoted Hlx, which is expressed within specific hematopoietic lineages. The cDNA sequence indicates that Hlx differs markedly from known vertebrate homeo box genes, and linkage analysis of an interspecific murine backcross showed that it resides at a novel homeo box locus on the distal portion of mouse chromosome 1. The Hlx homeo domain is most similar to that of the Drosophila H2.0 gene, but outside this region the two polypeptides are related only within a few short segments, the most notable being a motif (denoted Hep) also partially conserved in the engrailed and invected homeo proteins and possibly related to an octapeptide in certain paired box proteins. The presence of an intron within the Hlx homeo box at the same position as in several divergent Drosophila genes (H2.0, labial, Distal-less, proboscipedia, Abdominal-B, NK-1) suggests an ancient evolutionary relationship between these genes. RNA analysis of 67 murine hematopoietic cell lines and normal hematopoietic cells revealed Hlx expression throughout the myeloid/macrophage lineage and at early stages of B lymphocyte development but not in T lymphocytes, erythroid cells, or mast cells. Hence, Hlx is a candidate regulator of hematopoietic lineage commitment and maturation. It probably also functions outside the hematopoietic system, however, because Hlx mRNA could be detected in diverse adult tissues and in embryos from as early as day 8 of development.

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A mouse homeo box - containing gene maps near a developmental mutation

Cited by 17 publications

References 6 publications

Cloning and Sequencing of the MouseGli2Gene: Localization to theDominant hemimeliaCritical Region

Cloning and Sequencing of the MouseGli2Gene: Localization to theDominant hemimeliaCritical Region

The HOX complex neighbored by the EVX gene, as well as two other homeobox‐containing genes, the GBX‐class and the EN‐class, are located on the same chromosomes 2 and 7 in humans

Novel murine homeo box gene on chromosome 1 expressed in specific hematopoietic lineages and during embryogenesis.

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