A Mouse Gene Encoding an Oocyte Antigen Associated with Autoimmune Premature Ovarian Failure

Tong, Zhi-Bin; Nelson, Lawrence M.

doi:10.1210/endo.140.8.6911

Cited by 85 publications

(33 citation statements)

References 38 publications

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“…3), an established oocyte-specific (cytoplasmic) protein [11,12]. The latter, like NALP14, was endowed with a 320-residue N-terminal-based NACHT NTPase domain and a C-terminal-based LRR domain (14 repeats), a structure known to be critical for protein-protein interactions [13].…”

Section: Characterization Of the Germ Cell Family Of Lrr-replete Nachmentioning

confidence: 99%

The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family1

Horikawa

Kirkman

Mayo

et al. 2005

Biology of Reproduction

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Microscopy of sectioned neonatal mouse ovaries established the predominance of primordial follicles in Day 3 samples and the predominance of primary follicles by Day 8. To identify genetic determinants of the primordial to primary follicle transition, the transcriptome of Day 1 or Day 3 mouse ovaries was contrasted by differential display with that of Day 8 ovaries. This manuscript examines one of the up-regulated genes, the novel Nalp14 gene, whose transcript displayed 18- and 127-fold increments from Day 1 to Days 3 and 8, respectively. First noted by in situ hybridization in oocytes encased by primary follicles, Nalp14 transcripts were continuously expressed through the preovulatory stage. The transcripts declined when meiotic maturation resumed, and they were markedly diminished by the 2-cell embryo stage. The corresponding 3281-base pair, full-length cDNA coded for a 993 residue/104.6-kDa germ cell-specific protein. A member of the multifunctional NACHT NTPase family, the NALP14 protein featured 14 iterations of the leucine-rich-repeat domain, a region implicated in protein-protein interaction. Protein BLAST analysis of the NALP14 sequence revealed 2 previously reported germ cell-specific homologs (i.e., MATER [Maternal Antigen That Embryos Require], RNH2 [RiboNuclease/Angiogenin Inhibitor 2], and NALP4c). The structural attributes, expression pattern, and cellular localization of MATER and RNH2 largely conformed to those reported for NALP14.

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Section: Characterization Of the Germ Cell Family Of Lrr-replete Nachmentioning

confidence: 99%

The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family1

Horikawa

Kirkman

Mayo

et al. 2005

Biology of Reproduction

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“…In the thymectomized mouse model of ovarian autoimmunity, a unique ooplasm-specific protein reacting with autoantibodies was identified by screening a mouse ovary expression library. 131 The mouse protein, identified as MATER (maternal antigen that embryos require) 131a,b and its human homologue 131c are highly conserved. It is not clear yet if the MATER antigen is relevant to human ovarian autoimmune disease.…”

Section: Antigensmentioning

confidence: 99%

Ovarian Autoimmune Disease and Ovarian Autoantibodies

Luborsky

2002

Journal of Women's Health & Gender-Based Medicine

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Detection of specific autoantibodies remains the most practical clinical and research marker of autoimmune disease. The lack of consensus on ovary specific antibodies as a marker for ovarian autoimmunity has clinical and research consequences. The objective of this review is to summarize the evidence for ovarian autoimmunity and the detection of ovary specific autoantibodies in humans. Evidence favors the presence of an autoimmune disease of the ovary. Ovarian autoantibodies are associated primarily with premature ovarian failure (POF) and unexplained infertility. Variations in detection of ovarian autoantibodies are likely to be due to study design elements such as antibody test format, antigen preparation, and criteria for study and comparison groups. In addition, multiple targets appear to be involved in ovarian autoimmunity including ovarian cellular elements and oocyte related antigens. Many studies only assess one target antigen, leaving individuals with ovarian autoimmunity unidentified. The next most significant advance in characterizing ovarian autoimmunity will be definitive identification of the specific antigens and development of standardized tests based on use of specific antigens.

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“…Six such maternal-effect genes have been characterized using knockout mouse models [9][10][11][12][13][14]. Maternal antigen that embryos required (MATER) was first identified as an ooplasm-specific protein [15] encoded by a single-copy gene that is transcribed in growing oocytes. Homozygous null Mater males and heterozygous females have normal fertility, although homozygous females are sterile.…”

Section: Introductionmentioning

confidence: 99%

Oogenesin Is a Novel Mouse Protein Expressed in Oocytes and Early Cleavage-Stage Embryos1

Minami

Aizawa

Ihara

et al. 2003

Biology of Reproduction

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We describe a new gene (Oogenesin) that is expressed through oogenesis and early embryogenesis in the mouse. De novo expression starts at 15.5 dpc (days postcoitum) in the ovary, which coincides with the start of oogenesis. The isolated cDNA was 1387 base pairs (bp) in length with a single open reading frame of 326 amino acids corresponding to a predicted molecular mass of 37 kDa with no significant homology to previously reported sequences. A remarkable characteristic of the gene is the presence of a leucine zipper structure at amino acid positions 131-152 and a leucine-rich domain at positions 131-254. Northern blot analysis demonstrated that the mRNA was present only in the ovary, in which it was expressed as a single transcript of approximately 1.7 kb. In situ hybridization revealed distinct signals in the oocytes in follicles at all stages (primordial to antral follicles). Western blot analysis demonstrated that the protein is expressed from oocytes to four-cell-stage embryos and that it has a little larger size (46 kDa) than the predicted size of 37. Immunohistochemical analysis of ovary sections revealed that the protein is also expressed specifically in oocytes in follicles at all stages. Furthermore, immunostaining of preimplantation embryos revealed that the protein localizes in nuclei at the late one-cell and early two-cell stages. These results suggest that the gene has some roles in zygotic transcription of early preimplantation embryos as well as folliculogenesis and oogenesis in the mouse.

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A Mouse Gene Encoding an Oocyte Antigen Associated with Autoimmune Premature Ovarian Failure

Cited by 85 publications

References 38 publications

The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family1

The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family1

Ovarian Autoimmune Disease and Ovarian Autoantibodies

Oogenesin Is a Novel Mouse Protein Expressed in Oocytes and Early Cleavage-Stage Embryos1

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