A morphological-histochemical study of neurodegenerative and regenerative processes in flexor and extensor collaterals of the sciatic nerve after crushing in the presence of PRP-1

Abstract

A comparative morphological and histochemical study of the dynamics of de and regenerative processes in the damaged sciatic nerve (SN) area was conducted in rats at different time points after crushing in the presence of proline rich peptide (PRP 1). We measured the activity of Ca 2+ dependent acid phos phatase (AP). At the fifth day after SN crushing on the site of injury, we observed changes in the directions of nerve fibers and disruption of their structure, in particular, swelling of Schwann hollow tubes. Later, we found proliferation of cells of the endoneurium and Schwann cells in the extensor bundle (N. peroneus communis), which promoted recovery of nerve fibers and was accompanied by appearance of the maximum activity AP. We also showed partial recovery of the flexor bundle (N. Gastrocnemius). At 17 days after the trauma, as a result of successful regeneration of the damaged nerve, we observed the recovery of nerve fibers and their structures, which confirms the neuroprotective characteristics of PRP 1Keywords: nerve crushing, extensor and flexcor collaterals of sciatic nerve, revealing of Ca 2+ dependent acidic phosphatase activity, PRP 1

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

“…It is shown that depressor post-stimulus manifestations in the form TD and PTD mediate GABA or glycine monoamines. Us shows the protective purpose of GABA in studies of nonspecific neurodegeneration, especially in the Deiters' nucleus (following unilateral labyrinthectomy) [51], in the spinal cord after lateral hemisection [53][54][55][56] on peripheral nerve injury [57][58][59][60][61], on amyloid model of AD [50,62,63] and also on the rotenone model of PD [64,65]; in neurons mainly the GABAergic nature, in which early involving depressor reactions are accompanied by the recovery process until its completion. Confirmation the assumption of the universal protective assignment of GABA-ergic inhibition is the fact that in some systems during development of the nervous system GABA promotes proliferation, migration, differentiation and maturation of the synapse, expression of the GABA(A) receptor [66].…”