A Morphologic Study of Lymphadenosis benigna cutis

Abstract

Two skin biopsies of lymphadenosis benigna cutis have been analyzed by morphological and immunological methods using monoclonal and polyclonal antibodies on cryostat and paraffin sections. Follicular structures containing active germinal centers are composed of identical cell types as germinal centers of normal lymphatic tissue, e.g. centrocytes, centroblasts, immature plasma cells, dendritic reticulum cells and some T lymphocytes. Outside and inbetween the secondary follicles the infiltrate is composed of small T lymphocytes (OKT-3⁺, focal positive acid phosphatase reaction). Among T lymphocytes the OK.T-4⁺ to OKT-8⁺ ratio was 2:1. Within these areas, consisting almost exclusively of T lymphocytes, cells with electron microscopical features of indeterminate cells and interdigitating reticulum cells were recognized. Those cells are OKT-6⁺. It can be concluded that in lymphadenosis benigna cutis the infiltrate of the dermis is composed of B and T cell areas which show the same microarchitecture and morphology as in normal lymphatic tissue.

Primary cutaneous B-cell lymphoma: A unique type of low-grade lymphoma. Clinicopathologic and immunologic study of 83 cases

“…Good response to local therapy with the absence of subsequent dissemination and their often cytologically bland appearance have led dermatologists and pathologists to doubt that a di-agnosis of lymphoma may be applied to such cases, hence, the term pseudolymphoma originated. [1][2][3][4][5][6][7] With the advent of immunohistochemical study8x9 and, quite recently, of DNA analysis," it is now clear that a light chain monoclonal restriction is present in a consistent part of these cases, and that they are monoclonal proliferations, and thus true lymphomas.] ]- I6 We report the clinical presentation and course of quite a large series of patients with primary cutaneous B-cell lymphoma (CBCL), and investigate in depth the cytoarchitectural and immunologic profile of the disease.…”

Alkaline Phosphatase Positive Lymphoma

“…These follicles have the same cellular composition as the germinal centers of reactive lymph nodes [21]. Follicle-like features are usually seen only in fresh lesions of pseudolymphoma and vanish as the lesions mature.…”

Lymphadenosis benigna cutis induced by iatrogenic contact dermatitis from dinitrochlorobenzene

“…Clinically, LABC is characterized by reddish‐brown, dome‐shaped, elastic‐hard papules and nodules. Histologically, dense cellular infiltration predominantly composed of lymphocytes in the dermis, with occasional formation of lymphoid follicles with germinal centres, has usually been observed (2).…”