A morphologic and histochemical study of metaplastic polyps of the colorectum

Jass, Jeremy R.; Filipe, M. I.; Abbas, S H; Falcon, Charles A. J.; Wilson, Yannoulla; Lovell, David

doi:10.1002/1097-0142(19840201)53:3<510::aid-cncr2820530324>3.0.co;2-o

Cited by 63 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inactivation of DPC4/ SMAD4 might result in the abnormal accumulation of mucin in cellular cytoplasm because of a disorder of extracellular matrix production by the aberrant transforming growth factor-h signal. One of the speculations for the serrated appearance has been the abnormal accumulation of mucin in cellular cytoplasm (19). These findings suggest that 18q21 allelic imbalance might be an important event in the morphogenesis of serrated adenomas, and inactivation of DPC4/SMAD4 at the 18q locus might be a key genetic alteration in these lesions.…”

Section: Discussionmentioning

confidence: 99%

Serrated Adenomas Have a Pattern of Genetic Alterations That Distinguishes Them from Other Colorectal Polyps

Yashiro

Laghi

Saito

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Serrated adenomas are characterized by serrated crypts with dysplasia, and are distinguished from other polyps by their histology, but the genetic basis of serrated adenomas is unknown. We investigated genetic alterations in colorectal polyps to determine if a specific pattern were associated with serrated adenomas. Methods: Sixty-six small (<10 mm) colorectal polyps were studied, including 11 hyperplastic polyps, 27 serrated adenomas, 9 tubular adenomas, 6 tubulovillous adenomas, and 3 villous adenomas. Allelic imbalance and microsatellite instability were detected by analysis of microsatellites on 5q, 18q, 17p, 2p, and 3p; K-ras mutations were detected by oligonucleotide hybridization.

show abstract

Section: Discussionmentioning

confidence: 99%

Serrated Adenomas Have a Pattern of Genetic Alterations That Distinguishes Them from Other Colorectal Polyps

Yashiro

Laghi

Saito

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Whereas six of 32 normal mucosal samples from the left colon gave a weak reaction with mPAS (table 2), 22 left sided cancers gave a weak reaction. This probably indicates an increased expression of Nacetyl sialic acid lacking in 0-acetyl groups within tumour mucus (presumably at the expense of 0-acetyl sialic acid).…”

Section: Mucin Profiles In Cancer V Adjacent Normal Mucosamentioning

confidence: 96%

“…22 The existence of heterogeneity in large bowel sialic acid in the general population may have important implications. We have shown that mPAS positive sialic acid is susceptible to neuraminidase digestion (unpublished observations) and are now studying possible associations between the secretion of this variant of sialic acid and susceptibility to ulcerative colitis.…”

mentioning

confidence: 99%

Colorectal goblet cell sialomucin heterogeneity: its relation to malignant disease.

Sugihara¹,

Jass²

1986

Journal of Clinical Pathology

View full text Add to dashboard Cite

SUMMARY Mucus secreted by colorectal cancer differs in three respects from that produced normally: an overall reduction, a loss of 0-acetyl substituents in sialic acid, and an increase in neutral mucin. Similar changes have been reported in apparently normal mucosa bordering colorectal cancer. "Normal" left sided colorectal mucosa from 32 patients with rectal cancer was studied. Each case was matched by age and sex to a patient with diverticular disease and a patient with irritable bowel syndrome. Twenty five patients with right sided cancer were matched to patients with Crohn's disease. Sections were stained with mild periodic acid Schiff (mPAS) (selectively stains N-acetyl sialic acid lacking in 0-acetyl group) and other closely related techniques. Reactions were graded negative, weak, and intense. An intense reaction was found in 9% of cases; there was no difference between the various matched groups. Phenylhydrazine interposition failed to block the mPAS effect, indicating that a positive result was due to a deficiency of sialic acid with 0-acetyl substituents rather than neutral mucin. Different staining patterns in left and right colon were probably due to differing ratios of total sialic acid:fucose. These findings indicate a hitherto unsuspected colorectal goblet cell sialomucin heterogeneity within the general population, but no association with neoplastic disease is apparent.Colorectal goblet cells are believed to secrete mainly acid mucin but also small amounts of neutral mucin. IThere are important regional differences in the colon. The right colon secretes more neutral mucin2 (higher molar ratio of fucose:sialic acid) and expresses more (fucose rich) blood group antigens. Biochemical differences are found in sialic acid, with greater sensitivity to neuraminidase digestion being evidenced by saponified sialic acid in the left colon.2 The structural basis of this change is not known. Most sialic acid residues bear 0-acetyl groups in the polyhydroxy side chain or at position C4, or both.Colorectal cancer usually secretes less mucus than normal mucosa, which hinders its detailed characterisation. Biochemical and histochemical studies, however, have shown important qualitative changes.These include an increase in the amount of neutral mucin and a reduction in the proportion of side chain and C4 substituted sialic acid.2 Modified periodic acid Schiff techniques, periodate borohydride/potassium Accepted for publication I May 1986 hydroxide/periodic acid Schiff (PB/KOH/PAS)3 and periodate thionin Schiff/potassium hydroxide/ periodic acid Schiff (PT/KOH/PAS)4, were developed by Culling et al to show changes in sialic acid composition-that is, loss of 0-acetyl substituents and increased expression of N-acetyl sialic acid. Unfortunately, neither of these methods distinguishes N-acetyl sialic acid from neutral mucin; both are oxidised by periodic acid. This important lack of specificity has now been corrected, but earlier conclusions are open to question.Several groups have reported "cancer-associated" chang...

show abstract

“…Mucus, secreted by hyperplastic polyps, is more Pas-positive than from normal goblet-cell mucus. 13 Hyperplastic epithelium shows increased expression of carcinoembryonic antigen 13 and reduced secretory component and immunoglobulin (Ig)a. TM Cells of hyperplastic polyps migrate from the crypt to the zone of exfoliation at much slower rates than normal, probably as a result of delayed exfoliation at the end of the cell cycle. 15 Some of these changes also are observed in neoplastic lesions.…”

Section: Introductionmentioning

confidence: 99%

Diet, alcohol, and smoking and the occurrence of hyperplastic polyps of the colon and rectum (United States)

Kearney¹,

Giovannucci²,

Rimm³

et al. 1995

Cancer Causes Control

View full text Add to dashboard Cite

Hyperplastic polyps of the colon reveal a geographic distribution similar to that of colorectal cancer and adenomatous polyps. However, unlike adenomas--known precursors of colorectal cancer--little is known about the etiology or clinical significance of the hyperplastic polyp. In this prospective study, we set out to determine the main dietary and other lifestyle factors in the United States that might be associated with this lesion. Hyperplastic polyps of the distal colon and rectum were diagnosed in 219 of 12,922 men of the Health Professionals Follow-up Study having had an endoscopic procedure between 1986 and 1992, and 175 of 15,339 women of the Nurses' Health Study who had undergone an endoscopy for a variety of reasons between 1980 and 1990. After adjusting for age, family history of colon cancer, history of previous endoscopy, and total energy intake using multiple logistic regression, those consuming 30 g or more of alcohol per day were at increased risk relative to nondrinkers among men (relative risk [RR] = 1.69; 95 percent confidence interval [CI] = 1.01-2.80) and women (RR = 1.79, CI = 1.02-3.15). Current smoking also was found to be associated strongly positively with hyperplastic polyps in men (RR = 2.45, CI = 1.59-3.75) and women (RR = 1.96, CI = 1.16-2.86). High intake of folate was associated inversely with risk in both men (RR = 0.74, CI = 0.49-1.11, between high and low intakes of folate) and women (RR = 0.45, CI = 0.28-0.74, between high and low intakes of folate). Among macronutrients, a suggestive increase in risk existed with intake of animal fat, although this was attenuated in the full multivariate model (RR[men] = 1.48, CI = 0.94-2.41, and RR[women] = 1.22, CI = 0.77-1.94) between high and low quantities of animal fat intake. These prospective data provide evidence of associations between low folate intake, alcohol consumption, and current cigarette smoking, and risk of hyperplastic polyps of the distal colon and rectum. These same factors also have been found to be related to adenoma and cancer of the colon. The hyperplastic polyp is an indicator of populations at high risk for colorectal carcinoma, and it also may serve as a marker for factors that influence neoplastic evolution.

show abstract

A morphologic and histochemical study of metaplastic polyps of the colorectum

Cited by 63 publications

References 24 publications

Serrated Adenomas Have a Pattern of Genetic Alterations That Distinguishes Them from Other Colorectal Polyps

Serrated Adenomas Have a Pattern of Genetic Alterations That Distinguishes Them from Other Colorectal Polyps

Colorectal goblet cell sialomucin heterogeneity: its relation to malignant disease.

Diet, alcohol, and smoking and the occurrence of hyperplastic polyps of the colon and rectum (United States)

Contact Info

Product

Resources

About