A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

Valkenburg, Olivier; Steegers‐Theunissen, R.P.M.; Smedts, H.P.M.; Dallinga‐Thie, Geesje M.; Fauser, Bart C.J.M.; Westerveld, Egbertine H.; Laven, Joop S.E.

doi:10.1210/jc.2007-1756

Cited by 170 publications

(148 citation statements)

References 34 publications

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“…Women with polycystic ovary syndrome have an abnormal lipid profile, characterized by elevated triglyceride and reduced HDL-C levels. 104,105 In FM transsexuals, testosterone administration has been associated with a reduction in HDL-C and an increase of triglyceride levels. 83 In obese, postmenopausal women administration of nandrolone decanoate 86 causes a decrease in HDL-C and an increase in LDL-C levels.…”

Section: Lipid Profilementioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

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Section: Lipid Profilementioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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“…Several cardiovascular risk factors, including dyslipidemia (7,8), impaired glucose metabolism (9), abdominal obesity (10), and the metabolic syndrome (11), are more prevalent in PCOS women than in the general population and possibly contribute to the greater cardiovascular morbidity and mortality in PCOS. Of note, women diagnosed with PCOS according to the 1990 criteria have more adverse metabolic profile than those diagnosed according to the additional 2003 criteria (12,13).…”

Section: Introductionmentioning

confidence: 99%

Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels

Koiou

Τζιόμαλος

Katsikis

et al. 2011

European Journal of Endocrinology

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Objective: Women with polycystic ovary syndrome (PCOS) appear to have higher cardiovascular risk than healthy population. Patients diagnosed with PCOS according to the 1990 criteria have a more adverse metabolic profile than those diagnosed with the 2003 criteria. Platelet-derived microparticles (PMPs) appear to contribute to atherosclerosis but have not been assessed in PCOS. The aim of this study was to determine plasma PMPs in PCOS patients. Design: A cross-sectional study. Methods:We assessed plasma PMPs in 76 normal weight women with PCOS (39 belonging to the phenotypes 1 and 2 (group I) and 37 belonging to the phenotypes 3 and 4 (group II)) and 21 healthy normal weight women. Results: Markers of obesity and insulin resistance did not differ between women with PCOS and controls. Serum testosterone levels and the free androgen index (FAI) were higher in group I than in group II and controls (P!0.001 for all comparisons) but did not differ between the latter two groups. Plasma PMPs were higher in group I than in controls (PZ0.018) but did not differ between group II and controls or between groups I and II. In the total study population (nZ97), plasma PMPs correlated with serum testosterone levels (rZ0.207, PZ0.042) and the FAI (rZ0.207, PZ0.042). Conclusions: Plasma PMPs are elevated in women with phenotypes 1 and 2 of PCOS compared with healthy controls, but not in women with phenotypes 3 and 4. Hyperandrogenemia, which is more pronounced in phenotypes 1 and 2, appears to be implicated in the increase in plasma PMPs.

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“…Piia [24] found that triacylglycerol is exchanged for cholesterol esters by activity of cholesteryl ester transfer protein. This process results in triacylglycerol enriched HDL-C which catabolized more rapidly [25]. The AMPK (AMP-activated protein kinase) is an intracellular energy and nutrient sensor [26], sterol regulatory element binding protein (SREBP) is a key regulator of intracellular lipid metabolism that it considered the substrate of AMPK, where mRNA of hepatic SREBP-2 and SREBP-1c are linked with AMPK inhibition in obesity-induced insulin-resistant, that correlates with an increase in hepatic expression of SREBP-2 and SREBP-1c and its target genes [27].…”

Section: Discussionmentioning

confidence: 99%

Effect of Western Style Diet on NLRP3 Inflammasome and its Correlation with Metabolic Syndromes

Hamid¹,

Habib²,

El-Arab³

et al. 2017

International Journal of Clinical Chemistry and Laboratory Medi

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A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

Abstract: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

Cited by 170 publications

References 34 publications

Testosterone, SHBG and cardiovascular health in postmenopausal women

Testosterone, SHBG and cardiovascular health in postmenopausal women

Circulating platelet-derived microparticles are elevated in women with polycystic ovary syndrome diagnosed with the 1990 criteria and correlate with serum testosterone levels

Effect of Western Style Diet on NLRP3 Inflammasome and its Correlation with Metabolic Syndromes

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