Wireless sensor network (WSN) is a research hot spot of scholars in recent years, in which node localization technology is one of the key technologies in the field of wireless sensor network. At present, there are more researches on static node localization, but relatively few on mobile node localization. The Monte Carlo mobile node localization algorithm utilizes the mobility of nodes to overcome the impact of node velocity on positioning accuracy. However, there are still several problems: first, the demand for anchor nodes is large, which makes the positioning cost too high; second, the sampling efficiency is low, and it is easy to fall into the infinite loop of sampling and filtering; and third, the positioning accuracy and positioning coverage are not high. In order to solve the above three problems, this paper proposes a Monte Carlo node location algorithm based on improved QUasi-Affine TRansformation Evolutionary (QUATRE) optimization. The algorithm firstly selects the high-quality common nodes in the range of one hop of unknown nodes as temporary anchor nodes, and takes the temporary anchor nodes and anchor nodes as the reference nodes for positioning, so as to construct a more accurate sampling area; then, the improved QUATRE optimization algorithm is used to obtain the estimated location of unknown nodes in the sampling area. Simulation experiments show that the Monte Carlo node positioning algorithm based on the improved QUATRE optimization has higher positioning accuracy and positioning coverage, especially when the number of anchor nodes is relatively small.