A Monte Carlo evaluation of carbon and lithium ions dose distributions in water

Taleei, Reza; Hultqvist, Martha; Gudowska, Irena; Nikjoo, Hooshang

doi:10.3109/09553002.2011.624572

Cited by 10 publications

(8 citation statements)

References 22 publications

(19 reference statements)

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“…As seen, the local dose at the TEPC center is generally 2-3 times higher than the TEPCmeasured and TEPC-simulated dose under the focused irradiation of this TEPC by 3 mm FWHM pencil-like beam. Our results suggest that a good agreement between measured and calculated doses can be obtained only by direct modeling of the TEPC geometry, and not by scoring the dose in simulations without TEPC, as done by other authors (Hultqvist et al 2010, Taleei et al 2011.…”

Section: Lineal Energy Spectra Inside the Water Phantomsupporting

confidence: 71%

“…Simulations with the PHITS code were done for a wallless TEPC (Tsuda et al 2010). The energy deposition inside and around 7 Li and 12 C beams in water were calculated with SHIELD-HIT and FLUKA codes (Hultqvist et al 2010, Taleei et al 2011), but without implementing the exact geometry of the TEPC detector and, respectively, without calculating y-distributions. The FLUKA code was also used to simulate responses of TEPC to various ions (Böhlen et al 2011), including y-distributions for TEPCs located on the beam axis inside a water phantom irradiated by 12 C beam (Böhlen et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Microdosimetry of radiation field from a therapeutic 12C beam in water: A study with Geant4 toolkit

Burigo

Pshenichnov

Mishustin

et al. 2013

Nuclear Instruments and Methods in Physics Research Section B:

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We model the responses of Tissue-Equivalent Proportional Counters (TEPC) to radiation fields of therapeutic 12 C beams in a water phantom and to quasimonoenergetic neutrons in a PMMA phantom. Simulations are performed with the Monte Carlo model for Heavy Ion Therapy (MCHIT) based on the Geant4 toolkit. The shapes of the calculated lineal energy spectra agree well with measurements in both cases. The influence of fragmentation reactions on the TEPC response to a narrow pencil-like beam with its width smaller than the TEPC diameter is investigated by Monte Carlo modeling. It is found that total lineal energy spectra are not very sensitive to the choice of the nuclear fragmentation model used. The calculated frequency-mean lineal energyȳ f differs from the data on the axis of a therapeutic beam by less than 10% and by 10-20% at other TEPC positions. The validation of MCHIT with neutron beams gives us confidence in estimating the contributions to lineal energy spectra due to secondary neutrons produced in water by 12 C nuclei. As found, the neutron contribution at 10 cm distance from the beam axis amounts to ∼ 50% close the entrance to the phantom and decreases to ∼ 25% at the depth of the Bragg peak and beyond it. The presented results can help in evaluating biological out-of-field doses in carbon-ion therapy.

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Section: Lineal Energy Spectra Inside the Water Phantomsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Microdosimetry of radiation field from a therapeutic 12C beam in water: A study with Geant4 toolkit

Burigo

Pshenichnov

Mishustin

et al. 2013

Nuclear Instruments and Methods in Physics Research Section B:

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“…24,25 The nuclear interaction cross sections used in the code and the obtained dose profiles in tissue-like media for proton and heavier ion beams have been shown to be in good agreement with available experimental data. 18,26,27 The 1 H and 12 C ions with initial energies 160 MeV and 290 MeV/u, respectively, were transported through a cylindrical water phantom of 10 cm in diameter and 30 cm in length. The cylinder was divided into slabs of 1 mm thickness.…”

Section: A Calculations Of Dose Contributions From Primary and Secmentioning

confidence: 99%

Microdosimetry of proton and carbon ions

Liamsuwan¹,

Hultqvist

Lindborg

et al. 2014

Medical Physics

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“…The simulated carbon‐ion beams were of rectangular shape with a constant beam height of 2.0 cm full width at half maximum (FWHM), while the beam widths varied in the interval from 0.5 to 10.0 mm (FWHM). A Gaussian‐distributed spread in kinetic energy of the incident carbon‐ions of 1.0% and a beam divergence of 1 mrad was assumed, as in other similar studies . A water phantom, of size 200 × 200 × 200 mm 3 , was used as simulation geometry.…”

Section: Methodsmentioning

confidence: 99%

Quantitative evaluation of potential irradiation geometries for carbon‐ion beam grid therapy

et al. 2018

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Purpose: Radiotherapy using grids containing cm-wide beam elements has been carried out sporadically for more than a century. During the past two decades, preclinical research on radiotherapy with grids containing small beam elements, 25 lm-0.7 mm wide, has been performed. Grid therapy with larger beam elements is technically easier to implement, but the normal tissue tolerance to the treatment is decreasing. In this work, a new approach in grid therapy, based on irradiations with grids containing narrow carbon-ion beam elements was evaluated dosimetrically. The aim formulated for the suggested treatment was to obtain a uniform target dose combined with well-defined grids in the irradiated normal tissue. The gain, obtained by crossfiring the carbon-ion beam grids over a simulated target volume, was quantitatively evaluated. Methods: The dose distributions produced by narrow rectangular carbon-ion beams in a water phantom were simulated with the PHITS Monte Carlo code. The beam-element height was set to 2.0 cm in the simulations, while the widths varied from 0.5 to 10.0 mm. A spread-out Bragg peak (SOBP) was then created for each beam element in the grid, to cover the target volume with dose in the depth direction. The dose distributions produced by the beam-grid irradiations were thereafter constructed by adding the dose profiles simulated for single beam elements. The variation of the valley-to-peak dose ratio (VPDR) with depth in water was thereafter evaluated. The separation of the beam elements inside the grids were determined for different irradiation geometries with a selection criterion. Results: The simulated carbon-ion beams remained narrow down to the depths of the Bragg peaks. With the formulated selection criterion, a beam-element separation which was close to the beam-element width was found optimal for grids containing 3.0-mm-wide beam elements, while a separation which was considerably larger than the beam-element width was found advantageous for grids containing 0.5-mm-wide beam elements. With the single-grid irradiation setup, the VPDRs were close to 1.0 already at a distance of several cm from the target. The valley doses given to the normal tissue at 0.5 cm distance from the target volume could be limited to less than 10% of the mean target dose if a crossfiring setup with four interlaced grids was used. Conclusions: The dose distributions produced by grids containing 0.5-and 3.0-mm wide beam elements had characteristics which could be useful for grid therapy. Grids containing mm-wide carbonion beam elements could be advantageous due to the technical ease with which these beams can be produced and delivered, despite the reduced threshold doses observed for early and late responding normal tissue for beams of millimeter width, compared to submillimetric beams. The treatment simulations showed that nearly homogeneous dose distributions could be created inside the target volumes, combined with low valley doses in the normal tissue located close to the target volume, if the carbon-ion beam grids w...

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A Monte Carlo evaluation of carbon and lithium ions dose distributions in water

Cited by 10 publications

References 22 publications

Microdosimetry of radiation field from a therapeutic 12C beam in water: A study with Geant4 toolkit

Microdosimetry of radiation field from a therapeutic 12C beam in water: A study with Geant4 toolkit

Microdosimetry of proton and carbon ions

Quantitative evaluation of potential irradiation geometries for carbon‐ion beam grid therapy

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