A Monte Carlo detector response model for the IRIS PET preclinical scanner

Pilleri, Alessandro; Camarlinghi, N.; Guerra, A. Del; Sportelli, Giancarlo; Belcari, Nicola

doi:10.1016/j.ejmp.2018.12.035

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Since these matrices require high loads of memory storage, symmetries and SRM sparsity have been exploited to reduce the SRM size. Some authors applied PSF descriptions [185,[204][205][206][207], or wide tubes-of-response (TORs) [208][209][210][211] instead of simple projection models. Other approaches include separate positron range correction, which is included in the reconstruction as an image blurring kernel [212,213].…”

Section: Iterative Methodsmentioning

confidence: 99%

Recent advances in combined Positron Emission Tomography and Magnetic Resonance Imaging

Galve,

Rodriguez-Vila,

Herraiz

et al. 2024

J. Inst.

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Hybrid imaging modalities combine two or more medical imaging techniques offering exciting new possibilities to image the structure, function and biochemistry of the human body in far greater detail than has previously been possible to improve patient diagnosis. In this context, simultaneous Positron Emission Tomography and Magnetic Resonance (PET/MR) imaging offers great complementary information, but it also poses challenges from the point of view of hardware and software compatibility. The PET signal may interfere with the MR magnetic field and vice-versa, posing several challenges and constrains in the PET instrumentation for PET/MR systems. Additionally, anatomical maps are needed to properly apply attenuation and scatter corrections to the resulting reconstructed PET images, as well motion estimates to minimize the effects of movement throughout the acquisition. In this review, we summarize the instrumentation implemented in modern PET scanners to overcome these limitations, describing the historical development of hybrid PET/MR scanners. We pay special attention to the methods used in PET to achieve attenuation, scatter and motion correction when it is combined with MR, and how both imaging modalities may be combined in PET image reconstruction algorithms.

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Section: Iterative Methodsmentioning

confidence: 99%

Recent advances in combined Positron Emission Tomography and Magnetic Resonance Imaging

Galve,

Rodriguez-Vila,

Herraiz

et al. 2024

J. Inst.

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“…We reconstruct the radiotracer distribution in a (68 × 68 × 100) mm 3 image volume of (170 × 170 × 250) voxels of size (0.4 × 0.4 × 0.4) mm 3 .…”

Section: Ii2 Image Reconstructionmentioning

confidence: 99%

“…Current and pre-clinical PET scanners reaching millimeter-level resolution over fields of view of tens of centimeters require heavy matrices for their image reconstruction. Various techniques have been proposed to compute SRMs, ranging from experimental determination of the matrix [1], analytical description of the γ interactions [2], or full MC simulations [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Monte-Carlo-based System Response Matrix Completeness and its Impact on Image Quality in Positron Emission Tomography

Hourlier¹,

Giovagnoli²,

Bekaert³

et al. 2022

Preprint

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“…Several preclinical PET scanners were recently developed for high resolution imaging using pixelated scintillator arrays coupled to photomultiplier tubes (PMT) (Belcari et al 2017, Pilleri et al 2019, position sensitive PMT (Bao et al 2009, Wang et al 2015, Pei et al 2019, Teuho et al 2019, Amirrashedi et al 2019, avalanche photodiodes (APD) (Bergeron et al 2009, 2014, Vrigneaud et al 2017 and silicon photomultiplier (Weissler et al 2015, Ko et al 2016, Omidvari et al 2017, Hallen et al 2018, Vrigneaud et al 2018, Stortz et al 2018, Sajedi et al 2019, Lee et al 2019, Son et al 2020. Preclinical PET scanners based on a monolithic crystal were also developed for high sensitivity PET imaging (Krishnamoorthy et al 2018, Xu et al 2019.…”

Section: Introductionmentioning

confidence: 99%

Performance evaluation of the mouse version of the LabPET II PET scanner

Gaudin¹,

Thibaudeau²,

Arpin³

et al. 2021

Phys. Med. Biol.

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The LabPET II is a new positron emission tomography technology platform designed to achieve submillimetric spatial resolution imaging using fully pixelated avalanche photodiodes-based detectors and highly integrated parallel front-end processing electronics. The detector was designed as a generic building block to develop devices for preclinical imaging of small to mid-sized animals and for clinical imaging of the human brain. The aim of this work is to assess the physical characteristics and imaging performance of the mouse version of LabPET II scanner following the NEMA NU4-2008 standard and using high resolution phantoms and in vivo imaging applications. A reconstructed spatial resolution of 0.78 mm (0.5 μ l) is measured close to the center of the radial field of view. With an energy window of 350 650 keV, the system absolute sensitivity is 1.2% and its maximum noise equivalent count rate reaches 61.1 kcps at 117 MBq. Submillimetric spatial resolution is achieved in a hot spot phantom and tiny bone structures were resolved with unprecedented contrast in the mouse. These results provide convincing evidence of the capabilities of the LabPET II technology for biomolecular imaging in preclinical research.

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A Monte Carlo detector response model for the IRIS PET preclinical scanner

Cited by 3 publications

References 17 publications

Recent advances in combined Positron Emission Tomography and Magnetic Resonance Imaging

Recent advances in combined Positron Emission Tomography and Magnetic Resonance Imaging

Evaluation of Monte-Carlo-based System Response Matrix Completeness and its Impact on Image Quality in Positron Emission Tomography

Performance evaluation of the mouse version of the LabPET II PET scanner

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