“…MSP1 is synthesized as an B195-kDa glycosyl phosphatidylinositol-anchored precursor that assembles as a complex with two peripheral membrane proteins called MSP6 and MSP7 (Holder et al, 1985;Stafford et al, 1996;Pachebat et al, 2001;Trucco et al, 2001;Kauth et al, 2003Kauth et al, , 2006. The MSP1/ 6/7 complex is abundant, uniformly coats the merozoite surface and is involved in the receptor-mediated interactions that initiate erythrocyte invasion (Su et al, 1993;Goel et al, 2003;Li et al, 2004). Just prior to egress, all three MSPs undergo a series of precise 'primary' proteolytic cleavage events (Freeman and Holder, 1983;Lyon et al, 1986Lyon et al, , 1987Holder et al, 1987;McBride and Heidrich, 1987;Stafford et al, 1994;Pachebat et al, 2007).…”