A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

Abstract

The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme‐mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis‐mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)‐like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment‐responsive and ultrasound‐mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few‐layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T‐BTO) and modified with pH‐responsive cinnamaldehyde (CA). The integration of pH‐responsive CA‐mediated H2O2 self‐supply, ultrasound‐mediated charge‐enhanced enzymatic activity, and glutathione (GSH) depletion enables out‐of‐balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.

Photodynamically Functionalized CoP/MoS2 Nanocomposites with Antibacterial Activity

“…8,9 Due to the advantages of easy preparation, costeffectiveness, weak toxicity, high biodegradability, and fast excretion, MoS 2 has become another hot research topic after graphene. 10 Compared with graphene, MoS 2 has higher sensitivity and can be used as high-quality nanoprobes for optical sensing, 11 biological imaging, 12 cancer treatment, 13 antibacterial activity, 14,15 and wound healing. 16,17 MoS 2 is recommended for photothermal therapy of cancer treatment 18,19 and antibacterial activity 20 ever, the narrow band gap (1.9 eV) of MoS 2 makes it easier to recombine photogenerated carriers, greatly limiting the antimicrobial activity of MoS 2 .…”

Mercaptosuccinic Acid-Based Carbon Quantum Dots as Peroxidase-like Nanozymes Inducing Cell Pyroptosis for Tumor-Specific Therapy

“…19 Most conventional Fe-based POD-like nanozymes in Fenton reaction are only sensitive to low pH (2.0−4.0), which remains a huge gap to be overcome for their practical application in TME-based tumor treatment. 20 Therefore, some efforts of increasing the number of dispersed active sites have been put to boost the catalytic performance of nanozymes. For instance, the nanozymes are to be constructed by single-atom metals other than Fe, and to construct the composite nanozymes by multiple metals (Cu/Fe, Fe/Ni).…”