A molecule-imprinted polyaniline membrane modified on carbon fiber for detection of glycine

Zeng, Hongjuan; Wang, Deshun; Yu, Junsheng

doi:10.3233/bme-130907

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…GCA is a conjugate of cholic acid (CA) and glycine. The MIPs for cholic acid (Yanez et al, 2010), bile salt derivatives (Awino and Zhao, 2013) and glycine (Zeng et al, 2013) have been prepared. However, the MIP for GCA has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Macromolecular Crowding Agents‐Assisted Imprinted Polymers For Analysis Of Glycocholic Acid In Human Plasma And Urine

Quan-Fu

Zhan

Zhong

et al. 2016

Biomedical Chromatography

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Glycocholic acid (GCA) is a newly identified biomarker for hepatocellular carcinoma (HCC) patients. In this study, a method based on macromolecular crowding strategy has been applied for preparation of a molecularly imprinted polymer (MIP), which possesses high adsorption capacity for GCA. Polymethyl methacrylate was used as a macromolecular crowding agent, N-(3-aminopropyl)-methacrylamide hydrochloride as a functional monomer and ethylene dimethacrylate as a cross-linker. The morphology and binding characteristics of MIP were assessed by scanning electron microscopy and absorption experiments. The MIP was used as an adsorbent material to separate GCA, and the molecularly imprinted solid-phase extraction (MISPE) was carefully optimized. The MISPE combined with high-performance liquid chromatographic analysis was successfully used to determine the GCA in plasma and urine samples. When spiked levels ranged from 0.2 to 20 μmol L , the recoveries were between 94.3 and 100.5%. As a proof of principle, this proposed method has been validated on a small subset of HCC patients (n = 10) and healthy volunteers (n = 10). The average GCA concentrations of HCC patients in plasma and urine were about 25 and 2.8 times than that of healthy volunteers. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Macromolecular Crowding Agents‐Assisted Imprinted Polymers For Analysis Of Glycocholic Acid In Human Plasma And Urine

Quan-Fu

Zhan

Zhong

et al. 2016

Biomedical Chromatography

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“…For electrochemical sensors using MIPs, conductive polymers are desirable because of their capability in electron-conducting through the bonding sites and matrix, leading the signal variation upon the recognition of target molecules [32][33][34][35]. Polyaniline (PANI), one of the typical conductive polymers, gives a promising potential for being introduced by a molecular imprinting process because of economic and simple synthesis/doping procedures [32,[36][37][38]. The excellent capacitive nature and rapid charge/discharge capability of electroactive PANI provides applications such as supercapacitors [39][40][41][42] and controlled drug release systems [43].…”

Section: Introductionmentioning

confidence: 99%

Perfluorooctanesulfonic Acid Detection Using Molecularly Imprinted Polyaniline on a Paper Substrate

Chi

Chen

Kameoka

2020

Sensors

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Perfluorinated compounds like perfluorooctanesulfonic acid (PFOS) are synthetic water pollutants and have accumulated in environments for decades, causing a serious global health issue. Conventional assays rely on liquid chromatography and mass spectroscopy that are very expensive and complicated and thus limit the large-scale monitoring of PFOS in wastewater. To achieve low-cost and accurate detection of PFOS, we designed a paper-based sensor with molecularly imprinted polyaniline electrodes that have recognition sites specific to PFOS. The calibration curve of resistivity ratios as a function of PFOS concentrations has a linear range from 1 to 100 ppt with a coefficient of determination of 0.995. The estimated limit of detection is 1.02 ppt. We also investigated attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) spectra of the surface of the polyaniline (PANI) electrodes to propose the potential recognition sites in polyaniline matrix and the detection mechanism. This electrical paper sensor with low cost and excellent sensitivity and selectivity provides the potential for large-scale monitoring of wastewater.

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“…There are a relatively large number of publications dealing with the synthesis of PANi-based MIPs (PANi MIPs) for lowmolecular weight templates. PANi MIPs were successfully synthesized for determination of trinitrotoluene [34], 1,3-dinitrobenzene [35], flucarbazone [36], azithromycin [37], L-glycine [38], benzophenone-4 [39], lomefloxacin [40], and other antibiotics [41,42]. The self-assembly strategy to prepare surface imprinted PANi nanofibers for 4-hydroxybenzoic acid was described in [43].…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polyaniline for detection of horseradish peroxidase

Pidenko

Skibina

et al. 2020

Anal Bioanal Chem

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A new facile and fast approach to the synthesis of polyaniline (PANi) molecularly imprinted polymers (MIPs) based on aniline oxidative chemical polymerization was proposed for protein recognition. For the first time, a surface imprinting strategy was implemented for the synthesis of PANi MIPs on the inner surface of soft glass polycapillaries (PC) with a large (2237) number of individual microcapillaries. Two different PANi layers-(i) PANi film and (ii) protein imprinted PANi nanowires-were synthesized sequentially. Uniform and highly stable PANi film was synthesized by oxidative polymerization at pH< 1. The synthesis of PANi MIPs on the PANi film pre-coated surface improved the reproducibility of PANi MIP formation. PANi MIP nanowires were synthesized at "mild" conditions (pH > 4.5) to preserve the protein template activity. The binding of horseradish peroxidase (HRP) molecules on the PANi MIP selective sites was confirmed by photometry (TMB chromogenic reaction), SEM images, and FTIR spectroscopy. The developed PANi MIPs enable HRP determination with a limit of detection (LOD) as low as 1.00 and 0.07 ng mL −1 on the glass slips and PC, respectively. The PANi MIPs are characterized by high stability; they are reversible and selective to HRP. The proposed approach allows PANi MIPs to be obtained for proteins on different supports and to create new materials for separation and sensing.

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A molecule-imprinted polyaniline membrane modified on carbon fiber for detection of glycine

Cited by 4 publications

References 17 publications

Macromolecular Crowding Agents‐Assisted Imprinted Polymers For Analysis Of Glycocholic Acid In Human Plasma And Urine

Macromolecular Crowding Agents‐Assisted Imprinted Polymers For Analysis Of Glycocholic Acid In Human Plasma And Urine

Perfluorooctanesulfonic Acid Detection Using Molecularly Imprinted Polyaniline on a Paper Substrate

Molecularly imprinted polyaniline for detection of horseradish peroxidase

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