A molecularly imprinted polymer for the selective solid-phase extraction of dimethomorph from ginseng samples

Xu, Xuanwei; Liang, Shuang; Meng, Xianglong; Zhang, Min; Chen, Ying; Zhao, Dan; Li, Yueru

doi:10.1016/j.jchromb.2015.02.033

Cited by 17 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…value (entries 4-6). The optimization of the composition of a solvent system was also determined, and an increase in the proportion of EtOAc decreased the amount of adsorption (entries [6][7][8].…”

Section: Resultsmentioning

confidence: 99%

“…Molecularly imprinted polymers (MIPs) [1][2][3] have been energetically pursued in the field of molecular recognition, and various types of applications such as a stationary phase of HPLC, 4,5) solid-state extraction, 6) and chemical sensors 7,8) have been reported due to qualities such as synthetic simplicity, stability, and a high level of recognition selectivity.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A Study of the Strength of a Template Molecule—A Functional Monomer Interaction That Affects the Performance of Molecularly Imprinted Polymers and Its Application to Chiral Amplification

Yasuyama

Matsunaga

Ando

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

A novel type of molecularly imprinted polymer (MIP), N-benzoyl-(S)-valine anilide-imprinted polymer (IP-2), was prepared using hydrogen-bonding interactions as a main force in the pre-polymerization step. The performance of the IP-2 was evaluated via batch procedure and compared with a (S)-valine anilideimprinted polymer (IP-1) that was prepared using an ionic interaction that is stronger than hydrogen bonding. Although both polymers showed a preferential adsorbability for (S)-amino acid derivatives, different performances were observed in terms of adsorbability and enantioselectivity. In addition, the IP-2 was able to recognize the enantiomer of a valine-derived chiral catalyst. This phenomenon was applied to a chiral amplification reaction, and a highly selective asymmetric Mannich-type amination was achieved using the combination of a racemic catalyst and a MIP.Key words molecularly imprinted polymer; chiral recognition; (S)-benzoyl amino acid anilide; asymmetric amplification Molecularly imprinted polymers (MIPs)1-3) have been energetically pursued in the field of molecular recognition, and various types of applications such as a stationary phase of HPLC, 4,5) solid-state extraction, 6) and chemical sensors 7,8) have been reported due to qualities such as synthetic simplicity, stability, and a high level of recognition selectivity.There are several methods for the preparation of imprinted polymers, including acid-base interaction, simple hydrogen bonding, dipole-dipole interaction, and hydrophobic interaction at the pre-polymerization step. Among these, the acidbase interaction 4,5,9) and/or hydrogen bonding 10,11) are mainly used due to the effectiveness of bonding strength in regards to the tailor-made construction of three-dimentional binding sites.Therefore, MIPs prepared using an acid-base interaction appear to show a higher level of performance than those without such an ionic interaction. However, unexpectedly, only a few reports 12) described the comparison of the different performances of MIPs between the presence of acid-base interaction and the absence of such a strong interaction. Therefore, it would be desirable to establish a new methodology, which would enable a convenient and precise comparison of the performance of MIPs that could lead to the development of a new type of MIP.We previously reported 13) the evaluation of basic (S)-amino acid anilide (such as (S)-1)-imprinted MIPs that were prepared using an acid-base interaction by batch procedure that allowed independent observation of adsorbability and selectivity, which were not precisely measured by a HPLC column system.In this paper we describe the evaluation of the performance of neutral (S)-N-benzoyl amino acid anilide (such as (S)-5)-imprinted MIPs, which were prepared in the presence of a weaker hydrogen-bonding interaction in the pre-polymerization step, by batch procedure. We also report a MIP with a (S)-N-benzoyl valine anilide cavity and its application to chiral amplification (Fig. 1). ExperimentalGeneral Ethylene glycol dimethac...

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

A Study of the Strength of a Template Molecule—A Functional Monomer Interaction That Affects the Performance of Molecularly Imprinted Polymers and Its Application to Chiral Amplification

Yasuyama

Matsunaga

Ando

et al. 2017

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

show abstract

“…For information on the fungicidal properties of the title compound, see: Xu et al (2015). For related crystal structures, see: Chai & Liu (2011) Hydrogen-bond geometry (Å , ).…”

Section: Related Literaturementioning

confidence: 99%

Crystal structure of dimethomorph

et al. 2015

View full text Add to dashboard Cite

In the title compound, C21H22ClNO4 [systematic name: (E)-3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one], which is the morpholine fungicide dimethomorph, the dihedral angles between the mean planes of the central chlorophenyl and the terminal benzene and morpholine (r.m.s. deviation = 0.2233 Å) rings are 71.74 (6) and 63.65 (7)°, respectively. In the crystal, molecules are linked via C—H⋯O hydrogen bonds and weak Cl⋯π interactions [3.8539 (11) Å], forming a three-dimensional structure.

show abstract

“…MIPs gain certain interest due to their selectivity to target molecules [5]. In comparison with biological counterparts such as antibodies, enzymes or biological receptors, MIPs have superior advantages: easy to prepare, good physical and chemical stability, economic, and applicability in harsh chemical media without loss of binding features [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures

Inanan

Tüzmen²

2018

HJBC

View full text Add to dashboard Cite

Ö Z B u çalışma, farklı kalıp-monomer oranları kullanılarak hazırlanmış MIP nanoyapıları ile yapay insan plazmasından kolesterol adsorpsiyonunu sunmaktadır. CP'nin adsorpsiyon kapasitesi C3P ve CP3'e göre sırayla %19,9 ve %16,1 daha yüksektir ve CP'nin adsorpsiyon kapasitesi NIP nanoyapılarına göre önemli derecede yüksektir. Tüm seçicilik katsayıları ve bağıl seçicilik değerleri yapay insan plazması için 1'den büyüktür. Optimum koşullarda, hiperkolesterolemik plazmadan oldukça yüksek kolesterol (%95.33) adsorplanmıştır. Anahtar KelimelerKolesterol; moleküler baskılama; plazma; nanoyapılar. A B S T R A C TT his study reports cholesterol adsorption from artificial human plasma using MIP nanostructures prepared with different template:monomer ratios. The adsorption capacity of CP is 19.9% and 16.1% higher than those of C3P and CP3, respectively and adsorption capacity of CP is significantly higher than NIP nanostructures. All selectivity coefficients and relative selectivity values were higher than 1 for artificial human plasma. Under optimum conditions, considerably high cholesterol was adsorbed from hypercholesterolemic plasma (95.33 %).

show abstract

A molecularly imprinted polymer for the selective solid-phase extraction of dimethomorph from ginseng samples

Cited by 17 publications

References 18 publications

A Study of the Strength of a Template Molecule—A Functional Monomer Interaction That Affects the Performance of Molecularly Imprinted Polymers and Its Application to Chiral Amplification

A Study of the Strength of a Template Molecule—A Functional Monomer Interaction That Affects the Performance of Molecularly Imprinted Polymers and Its Application to Chiral Amplification

Crystal structure of dimethomorph

Cholesterol Adsorption from Artificial Human Plasma with Molecular Imprinted Polymeric Nanostructures

Contact Info

Product

Resources

About