A molecularly imprinted electrochemical sensor with dual functional monomers for selective determination of gatifloxacin

Huang, Yan; Sun, Xiaodong; Yang, Jing; Cao, Zhiyuan; Wang, Rujie; Li, Li; Ding, Yaping

doi:10.1007/s00604-023-05839-3

Cited by 9 publications

(2 citation statements)

References 32 publications

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“…As discussed earlier, an equivalent number of protons and electrons participate in the electrochemical oxidation of GAT. Therefore, it can be inferred that GAT electrooxidation involves two electron transfers coupled with two proton transfers, which is consistent with the previous studies . The electrooxidation mechanism of GAT on the UiO-66/MWCNT-COOH/GCE is illustrated in Figure F, which is in good agreement with the oxidation mechanism of ciprofloxacin .…”

Section: Resultssupporting

confidence: 90%

“…Therefore, it can be inferred that GAT electrooxidation involves two electron transfers coupled with two proton transfers, which is consistent with the previous studies. 60 The electrooxidation mechanism of GAT on the UiO-66/ MWCNT-COOH/GCE is illustrated in Figure 4F, which is in good agreement with the oxidation mechanism of ciprofloxacin. 61 GAT includes a second N4 amine on the piperazine ring, which is generally regarded as the main reaction site.…”

Section: Electrooxidation Mechanism Of Gatsupporting

confidence: 69%

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UiO-66/Carboxylated Multiwalled Carbon Nanotube Composites for Highly Efficient and Stable Voltammetric Sensors for Gatifloxacin

Wan,

Du,

Tuo

et al. 2023

ACS Appl. Nano Mater.

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The excessive use of gatifloxacin (GAT) can seriously pollute the environment and damage human health. Therefore, reliable detection of its concentration is essential for environmental protection and physical health. Herein, an efficient and stable voltammetric sensor based on zirconium-based metal–organic framework/carboxylated multiwalled nanotube nanocomposites (UiO-66/MWCNT-COOH) was constructed for the determination of GAT. The morphologies, microstructures, and electrochemical properties of UiO-66/MWCNT-COOH were investigated by using various microscopic, spectroscopic, and electrochemical techniques. UiO-66/MWCNT-COOH showed good electrocatalytic activity for GAT oxidation with remarkable voltammetric response signals, which was primarily attributed to the synergistic effect from UiO-66 and MWCNT-COOH. Electrochemical kinetics studies revealed that the electrocatalytic oxidation of GAT is an irreversible and diffusion-limited reaction involving two protons and two electrons. The anodic peak current of GAT is linearly correlated with GAT concentration in the range from 0.05 to 10 μM with a low detection limit of 0.0075 μM. Moreover, UiO-66/MWCNT-COOH demonstrated high selectivity, reproducibility, and repeatability as well as extraordinary long-term stability (at least 7 weeks). The proposed UiO-66/MWCNT-COOH reliably detected trace GAT in the effluent, milk, human serum, and eye drops with satisfactory recoveries. Together with its outstanding merits such as low cost, robust response, short assay time, and good sensitivity, the proposed sensor shows enormous prospects for in situ determination of multiple antibiotics.

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Section: Resultssupporting

confidence: 90%

Section: Electrooxidation Mechanism Of Gatsupporting

confidence: 69%