A molecular toolkit for heterologous protein secretion across Bacteroides species
Yu-Hsuan Yeh,
Vince W. Kelly,
Rahman Rahman Pour
et al.
Abstract:SummaryBacteroides species are abundant and prevalent stably colonizing members of the human gut microbiota, making them a promising chassis for developing long-term interventions for chronic diseases. Engineering these bacteria as on-site production and delivery vehicles for biologic drugs or diagnostics, however, requires efficient heterologous protein secretion tools, which are currently lacking. To address this limitation, we systematically investigated methods to enable heterologous protein secretion in B… Show more
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