A molecular signature for social isolation identified in the brain

Zilkha, Noga; Kimchi, Tali

doi:10.1038/d41586-018-05447-9

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…For example, individuals with greater social support might have better immune function [ 62 , 63 ]. Other pathways such as neuroendocrine mechanisms might also play a role [ 64 , 65 ]. A recent genome-wide association study (GWAS) identified 38 significant genetic variants for social interaction, highlighting the possible genetic basis for social isolation [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study

Wang

Zhang

Jiang

et al. 2022

BMC Med

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Background Although social isolation has been associated with a higher mortality risk, little is known about the potential different impacts of face-to-face and non-face-to-face isolation on mortality. We examined the prospective associations of four types of social isolation, including face-to-face isolation with co-inhabitants and non-co-inhabitants, non-face-to-face isolation, and club/organization isolation, with all-cause and cause-specific mortality separately. Methods This prospective cohort study included 30,430 adults in Guangzhou Biobank Cohort Study (GBCS), who were recruited during 2003–2008 and followed up till Dec 2019. Results During an average of 13.2 years of follow-up, 4933 deaths occurred during 396,466 person-years. Participants who lived alone had higher risks of all-cause (adjusted hazard ratio (AHR) 1.24; 95% confidence interval (CI) 1.04-1.49) and cardiovascular disease (CVD) (1.61; 1.20–2.03) mortality than those who had ≥ 3 co-habitant contact after adjustment for thirteen potential confounders. Compared with those who had ≥ 1 time/month non-co-inhabitant contact, those without such contact had higher risks of all-cause (1.60; 1.20–2.00) and CVD (1.91; 1.20–2.62) mortality. The corresponding AHR (95% CI) in participants without telephone/mail contact were 1.27 (1.14–1.42) for all-cause, 1.30 (1.08–1.56) for CVD, and 1.37 (1.12–1.67) for other-cause mortality. However, no association of club/organization contact with the above mortality and no association of all four types of isolation with cancer mortality were found. Conclusions In this cohort study, face-to-face and non-face-to-face isolation were both positively associated with all-cause, CVD-, and other-cause (but not cancer) mortality. Our finding suggests a need to promote non-face-to-face contact among middle-aged and older adults.

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Section: Discussionmentioning

confidence: 99%

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study

Wang

Zhang

Jiang

et al. 2022

BMC Med

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“…In adult mice and rats of both sexes, even a brief period of social isolation can cause an aversive, ‘loneliness-like’ brain state [ 129 ], prompting animals to seek social interactions [ 129 , 130 , 131 , 132 , 133 ] and elevating the salience of social reward [ 121 , 131 ]. Social isolation in rodents also leads to many negative behavioral effects in both sexes, including increased territoriality and aggression [ 123 , 133 , 134 , 135 , 136∗∗ , 137 , 138 , 139 , 140 ], elevated anxiety-related behaviors [ 141 ], and depression-like symptoms [ 141 , 142 , 143 , 144 ]. In socially monogamous adult prairie voles, for example, both sexes display depressive-like and anxiety-related behaviors when separated from their bonded partner of the opposite sex [ 142 , 145 , 146 , 147 , 148 , 149 ] ( Figure 1 ).…”

Section: Sex Differences In the Response To Social Isolationmentioning

confidence: 99%

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Zilkha

Sofer

Kashash

et al. 2021

Current Opinion in Neurobiology

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Social animal species present a vast repertoire of social interactions when encountering conspecifics. Reproduction-related behaviors, such as mating, parental care, and aggression, are some of the most rewarding types of social interactions and are also the most sexually dimorphic ones. This review focuses on rodent species and summarizes recent advances in neuroscience research that link sexually dimorphic reproductive behaviors to sexual dimorphism in their underlying neuronal circuits. Specifically, we present a few possible mechanisms governing sexually-dimorphic behaviors, by hypothalamic and reward-related brain regions. Sex differences in the neural response to social isolation in adulthood are also discussed, as well as future directions for comparative studies with naturally solitary species.

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“…At this point, it is difficult to speculate about precise neural mechanisms that could contribute to the effects of social context on alcohol drinking in HM2 cages. While there has been much research describing differences in gene expression and neurocircuits between socially and single-housed animals ( Siuda et al, 2014 ; Yorgason et al, 2016 ; Zilkha and Kimchi, 2018 ), previous studies have been primarily performed in the context of standard housing and might not apply to conditions found in HM2 cages.…”

Section: Discussionmentioning

confidence: 99%

Effects of social housing on alcohol intake in mice depend on the non-social environment

Johnson,

Zweig,

Zhang

et al. 2024

Front. Behav. Neurosci.

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BackgroundExcessive alcohol consumption leads to serious health problems. Mechanisms regulating the consumption of alcohol are insufficiently understood. Previous preclinical studies suggested that non-social environmental and social environmental complexities can regulate alcohol consumption in opposite directions. However, previous studies did not include all conditions and/or did not include female rodents. Therefore, in this study, we examined the effects of social versus single housing in standard versus non-standard housing conditions in male and female mice.MethodsAdult C57BL/6 J mice were housed in either standard shoebox cages or in automated Herdsman 2 (HM2) cages and exposed to a two-bottle choice procedure with 3% or 6% ethanol versus water for 5 days. The HM2 cages use radiotracking devices to measure the fluid consumption of individual mice in an undisturbed and automated manner. In both housing conditions, mice were housed either at one or at four per cage.ResultsIn standard cages, group housing of animals decreased alcohol consumption and water consumption. In HM2 cages, group housing significantly increased ethanol preference and decreased water intake. There were no significant differences in these effects between male and female animals. These observations were similar for 3 and 6% ethanol solutions but were more pronounced for the latter. The effects of social environment on ethanol preference in HM2 cages were accompanied by an increase in the number of approaches to the ethanol solution and a decrease in the number of approaches to water. The differences in ethanol intake could not be explained by differences in locomotor or exploratory activity as socially housed mice showed fewer non-consummatory visits to the ethanol solutions than single-housed animals. In addition, we observed that significant changes in behaviors measuring the approach to the fluid were not always accompanied by significant changes in fluid consumption, and vice versa, suggesting that it is important to assess both measures of motivation to consume alcohol.ConclusionOur results indicate that the direction of the effects of social environment on alcohol intake in mice depends on the non-social housing environment. Understanding mechanisms by which social and non-social housing conditions modulate alcohol intake could suggest approaches to counteract environmental factors enhancing hazardous alcohol consumption.

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A molecular signature for social isolation identified in the brain

Cited by 6 publications

References 16 publications

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study

Associations of face-to-face and non-face-to-face social isolation with all-cause and cause-specific mortality: 13-year follow-up of the Guangzhou Biobank Cohort study

The social network: Neural control of sex differences in reproductive behaviors, motivation, and response to social isolation

Effects of social housing on alcohol intake in mice depend on the non-social environment

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