1999
DOI: 10.1002/(sici)1097-0215(19991210)83:6<809::aid-ijc20>3.0.co;2-0
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A molecular model for the development of germ cell cancer

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Cited by 40 publications
(18 citation statements)
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“…Because of these data, hiwi might be an interesting candidate gene to explain the genetic linkage between the development of TGCTs and the telomeric end of chromosome 12. Moreover, this could explain the ®nding of gain of this chromosomal region in some TGCTs (Looijenga et al, 1999a(Looijenga et al, , 2000Rosenberg et al, 1999;and Lothe, personal communication). Increased hiwi dose might elevate the number or the mitotic activity of spermatogenic stem cells, just like when piwi is overexpressed (Cox et al, 2000).…”
Section: Discussionmentioning
confidence: 94%
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“…Because of these data, hiwi might be an interesting candidate gene to explain the genetic linkage between the development of TGCTs and the telomeric end of chromosome 12. Moreover, this could explain the ®nding of gain of this chromosomal region in some TGCTs (Looijenga et al, 1999a(Looijenga et al, , 2000Rosenberg et al, 1999;and Lothe, personal communication). Increased hiwi dose might elevate the number or the mitotic activity of spermatogenic stem cells, just like when piwi is overexpressed (Cox et al, 2000).…”
Section: Discussionmentioning
confidence: 94%
“…Within the human adult testis, two types of germ cell tumors are distinguished. The ®rst type of tumors are the seminomas and nonseminomas of adolescents and adults, also known as TGCTs, while the second type are the spermatocytic seminomas of the elderly (reviewed in Looijenga et al, 1999a;Looijenga and Oosterhuis, 1999b). Although these tumors have separate pathogenesis, as demonstrated by their clinical behavior (reviewed in Bosl and Motzer, 1997;Burke and Mosto®, 1993) and chromosomal constitution Looijenga et al, 2000;Rosenberg et al, 1998Rosenberg et al, , 1999van Echten et al, 1995), they all originate from the germ cell lineage.…”
Section: Introductionmentioning
confidence: 99%
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“…14,62,65 This model suggests that fetal gonocytes (primordial germ cells) may undergo abnormal cell division (polyploidization) due to mostly environmental factors in utero and give rise to IGCNU. Polyploidization precedes the formation of i(12p).…”
Section: Molecular Biology Of Germ Cell Tumorsmentioning
confidence: 99%