A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing

Sun, Xiaoyan; Chalmers, Laura; Fu, Xiaobing; Zhao, Min

doi:10.1089/wound.2011.0334

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Moreover, the colons of the mice given DSS + alcohol were shorter than those given DSS alone, and there was more IL-1β and IL-18 in the colonic tissue of the DSS + alcohol mice versus the DSS + vehicle group. UC is a cyclical disease, with some periods of intestinal repair mediated by increased IL-22 production (X. Sun, Chalmers, Fu, & Zhao, 2012).…”

Section: Alcohol Intestinal Mucosa and The Gut Microbiomementioning

confidence: 99%

Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Boule

Agudelo

et al. 2018

Alcohol

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On November 18, 2016 the 21st annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the Center for Translational Research and Education at Loyola University Chicago's Health Sciences Campus in Maywood, IL. The 2016 meeting focused broadly on alcohol and inflammation, epigenetics, and the microbiome. The four plenary sessions of the meeting were Alcohol, Inflammation, and Immunity; Alcohol and Epigenetics; Alcohol, Transcriptional Regulation, and Epigenetics; and Alcohol, Intestinal Mucosa, and the Gut Microbiome. Presentations in all sessions of the meeting explored putative underlying causes for chronic diseases and mortality associated with alcohol consumption, shedding light on future work and potential therapeutic targets to alleviate the negative effects of alcohol misuse.

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Section: Alcohol Intestinal Mucosa and The Gut Microbiomementioning

confidence: 99%

Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Boule

Agudelo

et al. 2018

Alcohol

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“…The local protective effect of IL-22 is believed to be through induction of intestinal mucus production and restoration of goblet cells [110]. Elevated systemic IL-22 induces hepatic production of the lipopolysaccharides (LPS) binding protein which abrogates its systemic and local inflammatory effects [30, 108, 111–114]. A similar role is seen in graft versus host disease (GVHD) where IL-22 protects intestinal stem cells from immune mediated damage[115].…”

Section: Introductionmentioning

confidence: 99%

Biological and pathological activities of interleukin-22

et al. 2016

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Interleukin (IL)-22, a member of the IL-10 family, is a cytokine secreted by several types of immune cells including IL-22+CD4+ T cells (Th22) and IL-22 expressing innate leukocytes (ILC22). Recent studies have demonstrated that IL-22 is a key component in mucosal barrier defense, tissue repair, epithelial cell survival and proliferation. Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection and malignancy. In this Review we summarize the expression and signaling pathway and functional characteristics of the IL-22 and IL-22 receptor axis in physiological and pathological scenarios, and discuss the potential to target IL-22 signaling to treat human diseases.

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“…A recent study showed that L-ornithine administered to mice resulted in goblet cell production, mucin secretion and cell proliferation, which are associated with a healthier gut environment (Qi et al, 2019). Together with these results, L-ornithine also induces accumulation of IL-22 in intestinal tissues (Qi et al, 2019), a cytokine involved in the reconstitution of gut epithelial cells, improving mucus production by goblet cells, increasing the production of antimicrobial peptides and modulating genes involved in wound healing (Sun et al, 2012). Overall, these observations suggest that histamine and L-ornithine might be important signaling molecules in DEC pathogenesis and merit further investigation.…”

Section: Discussionmentioning

confidence: 96%

Gut Microbiota-Metabolome Changes in Children With Diarrhea by Diarrheagenic E. coli

Gallardo

Izquierdo

Vidal

et al. 2020

Front. Cell. Infect. Microbiol.

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Background: Diarrheagenic Escherichia coli (DEC) strains are a main cause of diarrhea worldwide in children under 5 years old. DEC virulence is strongly regulated by environmental conditions and metabolites produced by the gut microbiota in the intestinal tract. In this study, we evaluated changes in gut microbiota-metabolome in children with or without diarrhea produced by DEC pathotypes. Goal: To determine gut microbiota composition and metabolome in stool samples obtained from healthy children and children with diarrhea positive for DEC pathotypes. Methods: We analyzed a total of 16 age-paired stool samples: 8 diarrheal samples positive for one DEC pathotype and 8 stool samples from healthy children. To identify the microbiota composition, we sequenced the V3-V4 region of the 16S rRNA and determined operational phylogenetic units (OPU). OPU were then used to predict metabolic pathways using the PICRUSt2 software. The presence of metabolites in stool samples was determined by LC-MS. A correlation analysis was performed with the main genera from each group and main metabolites. Bacteria associated with variance of main metabolites were identified using the MIMOSA2 software. Results: DEC and healthy groups showed a statistically different microbiota composition. A decrease in Firmicutes together with an increase in Bacteroidetes and Proteobacteria was found in the DEC group compared to the healthy group. Metabolic pathway predictions based on microbiota diversity showed that pathways involved in histidine and L-ornithine metabolism were significantly different between groups. A total of 88 metabolites detected by LC-MS were included in the metabolome analysis. We found higher levels of histamine and lower levels of ornithine in DEC samples than in the healthy group. Histamine and L-ornithine were associated with a specific microbiota species and the corresponding metabolic pathways. Conclusion: Stool samples from healthy children and children positive for DEC displayed a differential metabolome and microbiota composition. A strong correlation between a gut microbiota species and certain metabolites, such as histamine and L-ornithine, was found in the DEC group. This information might be useful to identify mechanisms and signaling molecules involved in the crosstalk between microbiota and DEC pathotypes.

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A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing

Cited by 6 publications

References 24 publications

Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Biological and pathological activities of interleukin-22

Gut Microbiota-Metabolome Changes in Children With Diarrhea by Diarrheagenic E. coli

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