A molecular epidemiology study in women from Upper Silesia, Poland

Motykiewicz, Grażyna; Michalska, Jadwiga; Pendzich, Joanna; Małusecka, Ewa; Stróżyk, M.; Kalinowska, Ewa; Butkiewicz, Dorota; Mielzynska, Danuta; Midro, Alina T.; Santella, Regina M.; Chorazy, M

doi:10.1016/s0378-4274(98)00072-1

Cited by 39 publications

(20 citation statements)

References 13 publications

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“…Nested case-control studies in the Nordic and Italian cohorts showed that chromosomal aberrations are an intermediate step in the carcinogenic pathway and are independent of exposure status, substantiating the role of chromosomal aberrations in cancer and indicating that they reflect both exposure and susceptibility (29,30). Chromosomal aberrations in adults have been widely studied in nonoccupational and occupational settings (28,29,(31)(32)(33). However, only two studies have measured chromosomal aberrations by fluorescence in situ hybridization (FISH) to monitor the impact of in utero environmental exposures, and sample sizes have been small (V 40 subjects; refs.…”

Section: Introductionmentioning

confidence: 99%

Chromosomal Aberrations in Cord Blood Are Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons

Bocskay¹,

Tang²,

Orjuela³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

108

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Molecular and traditional epidemiology studies have indicated a possible relationship between in utero environmental exposures and increased risk for childhood cancers, especially acute leukemias. Chromosomal aberrations have been associated with environmental exposures and cancer risk in adults. In order to more clearly define the association between prenatal exposures to carcinogenic polycyclic aromatic hydrocarbons (PAH) and chromosomal aberrations, chromosomal aberration frequencies were measured in a subset of 60 newborns from the Columbia Center for Children's Environmental Health (CCCEH) Prospective Cohort Study. The subset was composed of African American and Dominican, nonsmoking mother-newborn pairs residing in low-income neighborhoods of New York City, who were exposed to varying levels of airborne PAHs. Prenatal exposure was assessed by questionnaire, personal air monitoring during the third trimester, and PAH-DNA adducts in umbilical cord blood. Chromosomal aberrations were measured in cord blood lymphocytes by fluorescence in situ hybridization. PAH-DNA adducts were not associated with chromosomal aberrations. However, airborne PAHs were significantly associated with stable aberration frequencies in cord blood (P < 0.01). Moreover, stable aberration frequencies were significantly higher among African American newborns compared with Dominican, despite no significant differences in PAH exposure. These results show for the first time an association between prenatal exposure to airborne carcinogenic PAHs and chromosomal aberrations in cord blood, suggesting that such prenatal exposures have the potential to cause cytogenetic damage that has been related to increased cancer risk in other populations.

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Section: Introductionmentioning

confidence: 99%

Chromosomal Aberrations in Cord Blood Are Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons

Bocskay¹,

Tang²,

Orjuela³

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

108

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“…Many studies have revealed no or only a tentative effect of the GSTM1 null genotype on DNA adducts or urinary metabolites of PAHs ( Grinberg -Funes et al, 1994;Hemminki et al, 1997;Mooney et al, 1997;Motykiewicz et al, 1998;Nielsen et al, 1996 ). Instead, Binkova et al, 1998 reported a significant effect of the GSTM1 null genotype on urinary PAH metabolites and mutagenicity, but no effect on DNA adducts in WBCs of an environmentally exposed nonsmoking population.…”

Section: Introductionmentioning

confidence: 99%

“…Fereira et al ( 1994 ) concluded in a cross -sectional study on coke and graphiteelectrode -producing plant workers that, on a group level, urinary mutagenicity might contribute to the detection of workers exposed to genotoxic PAHs. Recently it has been demonstrated that PAH exposure-related urinary mutagenicity might vary depending on an individual's genetic characteristics (Bartsch et al, 1995;Gabbani et al, 1996;Hirvonen et al, 1994 ).Many studies have revealed no or only a tentative effect of the GSTM1 null genotype on DNA adducts or urinary metabolites of PAHs ( Grinberg -Funes et al, 1994;Hemminki et al, 1997;Mooney et al, 1997;Motykiewicz et al, 1998;Nielsen et al, 1996 ). Instead, Binkova et al, 1998 reported a significant effect of the GSTM1 null genotype on urinary PAH metabolites and mutagenicity, but no effect on DNA adducts in WBCs of an environmentally exposed nonsmoking population.…”

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confidence: 99%

The effect of relevant genotypes on PAH exposure-related biomarkers

Kuljukka-Rabb

Nylund

Vaaranrinta

et al. 2002

J Expo Sci Environ Epidemiol

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Polycyclic aromatic hydrocarbons ( PAHs ) in coke oven emissions cause a cancer risk to humans. In a comprehensive biomonitoring study among Estonian coke oven workers, we looked at the effect of genetic polymorphisms in metabolic enzymes on urinary mutagenicity, 1 -hydroxypyrene ( 1 -OHP ) concentration in urine, and aromatic DNA adducts in white blood cells ( WBCs ). Coke oven workers were sampled twice ( samplings I and II ), and controls only once at the time of sampling I. Urinary mutagenicity was measured using the Ames test. CYP1A1, microsomal epoxide hydrolase ( mEH ), and glutathione S -transferase ( GST ) genotypes were analyzed by polymerase chain reaction ( PCR ). Urinary mutagenicity did not differ between exposed and controls, but those coke oven workers who were smokers had significantly higher ( P= 0.0002 ) mutagenic activity in urine than nonsmokers. Urinary mutagenicity was moderately correlated to levels of 1 -OHP and aromatic DNA adducts, the P values ranging from 0.0005 to 0.002. Carriers of a variant allele in exon 4 of mEH ( Arg 139 ) had elevated urinary mutagenicity ( sampling I ). In addition, urine mutagenicity of persons with predicted high mEH activity was significantly higher. Smoking habit did not explain the differences observed in urinary mutagenicity between mEH phenotype or genotype subgroups. Variation in exon 3 of mEH ( His 113 ) was related to a significantly ( P= 0.01 ) higher 1 -OHP concentration in exposed workers ( sampling II ). Workers from sampling I who had an Arg 139 variation in mEH had lower levels of adducts in lymphocytes ( P= 0.01 ) than others, while airborne benzo[ a ]pyrene ( B[ a ]P ) and His 113 variation affected interactively on adduct levels. Our study shows that a comprehensive assessment of exposure is essential for elucidation of PAH exposure at a workplace. Even at high exposures metabolic polymorphisms seem to have some effect on biomarker levels, and should be assessed in biomonitoring studies. Journal of Exposure Analysis and Environmental Epidemiology ( 2002 ) 12, 81 -91 DOI: 10.1038 / sj / jea / 7500204Keywords: aromatic DNA adducts, coke oven workers, genetic polymorphism, 1 -hydroxypyrene, urine mutagenicity. IntroductionEpidemiological data show that exposure to polycyclic aromatic hydrocarbons (PAHs ) is possibly carcinogenic to humans and believed to be mainly responsible for an elevated lung cancer incidence among coke oven workers (International Agency for Research on Cancer (IARC ), 1983;( International Agency for Research on Cancer (IARC ), 1984 ). In addition, other carcinogens, such as aromatic amines and heterocyclic compounds, are known to be present in coke oven emissions (IARC, 1984). Recent studies reveal both high and low mean exposure levels in operating coke oven plants.Most carcinogenic chemicals, such as PAHs, need to be activated to electrophilic reactants by metabolism in vivo (Miller and Miller, 1981 ). It is known at present that many of the genes coding enzymes involved in activation and detoxification of PAHs are poly...

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“…In previous studies concerning occupational exposure, spot urine samples were collected to examine differences between before and after a work shift (Wu et al, 1998;Kim et al, 2005;Unwin et al, 2006). First morning urine samples were often used to assess PAH exposures in environmental settings (Motykiewicz et al, 1998;Chuang et al, 1999;Mucha et al, 2006). However, it still remains unknown as to how well the first morning urinary 1-OHP concentrations can reflect the daily average 1-OHP concentrations.…”

Section: Introductionmentioning

confidence: 99%

1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons

Han¹,

Duan

Zhang³

et al. 2007

J Expo Sci Environ Epidemiol

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Urinary 1-hydroxypyrene (1-OHP) has been suggested as an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs). However, it remains unknown whether a first morning urine sample can be used to reflect average exposure. In this paper, we examine intra-individual differences and interindividual associations between first morning voids and 24-h composite urine samples. The analysis was performed using data collected from 100 adults who had a wide range of PAH exposure due to differences in their occupation, e.g., coke oven workers vs. non-coke oven workers. For each subject, all the urine voids within each of two 24-h measurement periods were collected. Results showed a significant (40% to 62%) intra-individual difference between first morning voids and 24-h urinary 1-OHP concentrations (in ng/ml urine). Creatinine adjustments of 1-OHP concentrations (in mmol/mol urinary creatinine) reduced the intra-individual difference by approximately 10%. Across all the subjects, a high overall correlation (r ¼ 0.76) was observed between first morning and 24-h average 1-OHP concentrations. Work environment and sampling season were found to significantly affect the relationship between first morning and 24-h 1-OHP concentrations. An increase of 1 ng/ml of first morning urinary 1-OHP predicted an increase of 0.5 and 0.25 ng/ml of 24-h urinary 1-OHP for coke oven workers and non-coke oven workers, respectively. Data collected in a winter season showed a higher correlation between first morning and 24-h concentrations than data collected in a fall season. Creatinine adjustments did not significantly improve overall correlations between first morning void and 24-h measurements, but increased total variances for 24-h urines explained by first morning urines in coke workers.

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A molecular epidemiology study in women from Upper Silesia, Poland

Cited by 39 publications

References 13 publications

Chromosomal Aberrations in Cord Blood Are Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons

Chromosomal Aberrations in Cord Blood Are Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons

The effect of relevant genotypes on PAH exposure-related biomarkers

1-Hydroxypyrene concentrations in first morning voids and 24-h composite urine: intra- and inter-individual comparisons

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