A Molecular Dynamics Simulation Study of the Effects of βGln114 Mutation on the Dynamic Behavior of the Catalytic Site of the Tryptophan Synthase
Anupom Roy,
Mikko Karttunen
Abstract:L-tryptophan (l-Trp), a vital amino
acid for
the survival of various organisms, is synthesized by the enzyme tryptophan
synthase (TS) in organisms such as eubacteria, archaebacteria, protista,
fungi, and plantae. TS, a pyridoxal 5′-phosphate (PLP)-dependent
enzyme, comprises α and β subunits that typically form
an α2β2 tetramer. The enzyme’s
activity is regulated by the conformational switching of its α
and β subunits between the open (T state) and closed (R state)
conformations. Many microorganisms rely on TS… Show more
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