2002
DOI: 10.1016/s0098-1354(02)00127-8
|View full text |Cite
|
Sign up to set email alerts
|

A modular simulation package for fed-batch fermentation: penicillin production

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
371
0

Year Published

2006
2006
2024
2024

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 528 publications
(374 citation statements)
references
References 15 publications
3
371
0
Order By: Relevance
“…During this stage biomass growth rate must be kept constant to maintain high penicillin production. So a readily metabolisable sugar such as glucose is supplied continuously into the system instead of being added all at once at the beginning [4,3]. We obtain the batch data using a modular simulator (PenSim v2.0) for fed-batch fermentation developed by the monitoring and control group of the Illinois Institute of Technology in the year of 2002 [10].…”
Section: Process Descriptionmentioning
confidence: 99%
“…During this stage biomass growth rate must be kept constant to maintain high penicillin production. So a readily metabolisable sugar such as glucose is supplied continuously into the system instead of being added all at once at the beginning [4,3]. We obtain the batch data using a modular simulator (PenSim v2.0) for fed-batch fermentation developed by the monitoring and control group of the Illinois Institute of Technology in the year of 2002 [10].…”
Section: Process Descriptionmentioning
confidence: 99%
“…The unstructured model for penicillin production in a fed-batch fermentor given by Birol et al [22] has been used for simulation studies. The model consists of nine differential equations relating bioreactor states (biomass, substrate, product, dissolved oxygen, CO 2 parameters are given in Birol et al [22].…”
Section: Fed-batch Bioreactormentioning
confidence: 99%
“…The model consists of nine differential equations relating bioreactor states (biomass, substrate, product, dissolved oxygen, CO 2 parameters are given in Birol et al [22]. While carrying out the simulations, we assume that the bioreactor operates isothermally and the fermentor temperature is maintained at the optimum value (25°C) by a perfect temperature controller.…”
Section: Fed-batch Bioreactormentioning
confidence: 99%
See 1 more Smart Citation
“…A sample of this includes the works of Birol et al (2002), where the model of the penicillin production process has been extended by including additional input variables such as agitation power and aeration rates. Nielsen et al (2003) proposed an empirical correlation to represent the oxygen transfer coefficient for a bioreactor.…”
Section: Introductionmentioning
confidence: 99%