A modular mathematical model of exercise-induced changes in metabolism, signaling, and gene expression in human skeletal muscle

Akberdin, Ilya R.; In, Kiselev; Ss, Pintus; Rn, Sharipov; Ay, Vertyshev; Ol, Vinogradova; Dv, Popov; Fa, Kolpakov

doi:10.1101/2021.05.31.446385

Cited by 6 publications

(1 citation statement)

References 107 publications

(184 reference statements)

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“…The visual representation as well as defined properties of diagram elements are the basis for automatic generation of the corresponding Java code that is used to simulate the model in BioUML. All methodological details on visual modular modeling implemented in the platform are presented in the recent publication [9].…”

Section: Mathematical Modelingmentioning

confidence: 99%

On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19

Afonyushkin¹,

Akberdin²,

Kozlova³

et al. 2022

Preprint

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Patients with COVID-19 may develop pneumonia, severe symptoms of acute respiratory distress syndrome, and multiple organ failure. Nevertheless, the variety of forms of this disease, requires further research on the pathogenesis of this disease. Based on the analysis of published data on the concentrations of SARS-CoV-2 in biological fluids of the nasopharynx, lungs and intestines and using a developed modular model of the virus distribution in human tissue and organs, an assessment of the SARS-CoV-2 reproduction in various compartments of the body is presented. Most of viral particles can enter into the esophagus from nasopharynx. Entering viral particles into the gastrointestinal tract will obviously be accompanied by infection of the intestinal epithelium and accumulation of the virus in the intestinal lumen in an amount proportional their secretory and protein-synthetic activities. The relatively low concentration of SARS-CoV-2 in tissues implies an essential role of transport processes and redistribution of the virus from nasopharynx and intestines to lungs. The model simulations also supposes that sanitation of the nasopharynx mucosa at the initial stage of the infectious process considering inhibition of the virus accumulation by means of cellular and humoral responses has prospects for the use in medicine practice.

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Section: Mathematical Modelingmentioning

confidence: 99%

On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19

Afonyushkin¹,

Akberdin²,

Kozlova³

et al. 2022

Preprint

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Muscle Research: A Tour d’Horizon

Zancanaro

2022

IJMS

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Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools

Kutumova

Akberdin

Kiselev

et al. 2022

IJMS

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Cancer treatment and pharmaceutical development require targeted treatment and less toxic therapeutic intervention to achieve real progress against this disease. In this scenario, nanomedicine emerged as a reliable tool to improve drug pharmacokinetics and to translate to the clinical biologics based on large molecules. However, the ability of our body to recognize foreign objects together with carrier transport heterogeneity derived from the combination of particle physical and chemical properties, payload and surface modification, make the designing of effective carriers very difficult. In this scenario, physiologically based pharmacokinetic modeling can help to design the particles and eventually predict their ability to reach the target and treat the tumor. This effort is performed by scientists with specific expertise and skills and familiarity with artificial intelligence tools such as advanced software that are not usually in the “cords” of traditional medical or material researchers. The goal of this review was to highlight the advantages that computational modeling could provide to nanomedicine and bring together scientists with different background by portraying in the most simple way the work of computational developers through the description of the tools that they use to predict nanoparticle transport and tumor targeting in our body.

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A modular mathematical model of exercise-induced changes in metabolism, signaling, and gene expression in human skeletal muscle

Cited by 6 publications

References 107 publications

On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19

On the Essential Role of SARS-CoV-2 Localization in the Nasopharynx and Intestines in the Pathogenesis of COVID-19

Muscle Research: A Tour d’Horizon

Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools

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