A Modular, Kerf-Minimizing Approach for Therapeutic Ultrasound Phased Array Construction

Stocker, Greyson; Lundt, Jonathan; Sukovich, Jonathan R.; Miller, Ryan M.; Duryea, Alexander P.; Hall, Timothy L.; Xu, Zhen

doi:10.1109/tuffc.2022.3178291

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…This study simulated a histotripsy transducer designed for transcutaneous liver tumor ablation with dimensions closely matching those currently in clinical use (Stocker et al 2022). The transducer is a large aperture, spherically curved 750 kHz phased array with a 14.2 cm focal radius.…”

Section: The Suitability Of Using a Linear Acoustic Propagation Modelmentioning

confidence: 99%

Effects of phase aberration on transabdominal focusing for a large aperture, low f-number histotripsy transducer

Yeats¹,

Gupta²,

Xu³

et al. 2022

Phys. Med. Biol.

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Objective. Soft tissue phase aberration may be particularly severe for histotripsy due to large aperture and low f-number transducer geometries. This study investigated how phase aberration from human abdominal tissue affects focusing of a large, strongly curved histotripsy transducer. Approach. A computational model (k-Wave) was experimentally validated with ex vivo porcine abdominal tissue and used to simulate focusing a histotripsy transducer (radius: 14.2 cm, f-number: 0.62, central frequency fc: 750 kHz) through the human abdomen. Abdominal computed tomography images from 10 human subjects were segmented to create three-dimensional acoustic property maps. Simulations were performed focusing at 3 target locations in the liver of each subject with ideal phase correction, without phase correction, and after separately matching the sound speed of water and fat to non-fat soft tissue. Main results. Experimental validation in porcine abdominal tissue showed that simulated and measured arrival time differences agreed well (average error, ~0.10 acoustic cycles at fc). In simulations with human tissue, aberration created arrival time differences of 0.65 µs (~0.5 cycles) at the target and shifted the focus from the target by 6.8 mm (6.4 mm pre-focally along depth direction), on average. Ideal phase correction increased maximum pressure amplitude by 95%, on average. Matching the sound speed of water and fat to non-fat soft tissue decreased the average pre-focal shift by 3.6 and 0.5 mm and increased pressure amplitude by 2 and 69%, respectively. Significance. Soft tissue phase aberration of large aperture, low f-number histotripsy transducers is substantial despite low therapeutic frequencies. Phase correction could potentially recover significant pressure amplitude for transabdominal histotripsy. Additionally, different heterogeneity sources distinctly affect focusing quality. The water path strongly affects the focal shift, while irregular tissue boundaries (e.g. fat) dominate pressure loss.

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Section: The Suitability Of Using a Linear Acoustic Propagation Modelmentioning

confidence: 99%

Effects of phase aberration on transabdominal focusing for a large aperture, low f-number histotripsy transducer

Yeats¹,

Gupta²,

Xu³

et al. 2022

Phys. Med. Biol.

Self Cite

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Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse

Yeats

Sukovich

et al. 2023

Ultrasound in Medicine & Biology

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Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound

Xu,

Khokhlova,

Cho

et al. 2024

Annual Review of Biomedical Engineering

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Histotripsy is a relatively new therapeutic ultrasound technology to mechanically liquefy tissue into subcellular debris using high-amplitude focused ultrasound pulses. In contrast to conventional high-intensity focused ultrasound thermal therapy, histotripsy has specific clinical advantages: the capacity for real-time monitoring using ultrasound imaging, diminished heat sink effects resulting in lesions with sharp margins, effective removal of the treated tissue, a tissue-selective feature to preserve crucial structures, and immunostimulation. The technology is being evaluated in small and large animal models for treating cancer, thrombosis, hematomas, abscesses, and biofilms; enhancing tumor-specific immune response; and neurological applications. Histotripsy has been recently approved by the US Food and Drug Administration to treat liver tumors, with clinical trials undertaken for benign prostatic hyperplasia and renal tumors. This review outlines the physical principles of various types of histotripsy; presents major parameters of the technology and corresponding hardware and software, imaging methods, and bioeffects; and discusses the most promising preclinical and clinical applications. Expected final online publication date for the Annual Review of Biomedical Engineering, Volume 26 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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A Modular, Kerf-Minimizing Approach for Therapeutic Ultrasound Phased Array Construction

Cited by 3 publications

References 45 publications

Effects of phase aberration on transabdominal focusing for a large aperture, low f-number histotripsy transducer

Effects of phase aberration on transabdominal focusing for a large aperture, low f-number histotripsy transducer

Soft Tissue Aberration Correction for Histotripsy Using Acoustic Emissions From Cavitation Cloud Nucleation and Collapse

Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound

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