A Modular Approach to Structurally Diverse Bidentate Chelate Ligands for Transition Metal Catalysis

Solid-Phase Synthesis and Catalytic Screening of Polystyrene Supported Diphosphines

“…Consequently ligand design has evolved as a powerful tool in the development of superior catalysts. Despite considerable progress in organometallic chemistry in the last few decades, it is often not possible to rationally design ligands and thus the development of new catalysts, especially in industry, often relies on trial-and-error [9][10][11]. This in turn necessitates the fast synthesis and screening of large families of ligands [11][12][13][14][15][16][17].…”

Total Synthesis and Structure Revision of Halioxepine

“…For the endgame of the synthesis, an aldol‐type addition of TBS hydroquinone 23 to aldehyde 24 was envisioned [16] . For this, alcohol syn ‐22 was oxidized and treated with a magnesium salt derived from deprotonation of mono‐protected hydroquinone 23 [17] . The addition proceeded with high selectivity for the expected syn ‐diol which is proposed to proceed via a chelation‐controlled transition state.…”

Asymmetric catalytic arylation of ethyl glyoxylate using organoboron reagents and Rh(i)–phosphane and phosphane–phosphite catalysts

“…2): (R)-Phanephos (1), commonly used for asymmetric hydrogenations, 14 (R,R)-Chiraphos (2), (R)-MonoPhos (3) and other phosphoramidite type derivatives (4) and (5) were also employed. The results can be seen in Table 1.…”