A modified technique for the surgical correction of urethral diverticula using a porcine xenograft

Lee, James W. S.; Doumouchtsis, Stergios K.; Fynes, Michelle

doi:10.1007/s00192-008-0675-y

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…But, the recurrence rate has always been a problem affecting at least 24% of traditionally repaired rectocoeles [32]. Graft augmentation has been recommended by some authors in an effort to improve outcomes and decrease failure rates [33,34].…”

Section: Posterior Compartment Prolapsementioning

confidence: 99%

Complex pelvic floor failure and associated problems

Elneil¹

2009

Best Practice & Research Clinical Gastroenterology

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Section: Posterior Compartment Prolapsementioning

confidence: 99%

Complex pelvic floor failure and associated problems

Elneil¹

2009

Best Practice & Research Clinical Gastroenterology

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“…It acts as a scaffold for the surrounding tissue to grow, supports vessel growth, and fosters cellular differentiation and gets completely incorporated in it. [4] Surgisis ® is being used for various purposes in urology; urethral reconstruction,[5] ureteric reconstruction,[6] urethral diverticular surgery,[7] bladder neck fistula closure after exstrophy repair,[8] surgery for peyronie's disease, penile prosthetic surgery,[9] and nephron sparing surgery. [10] Surgisis ® is available in various sizes and for RUF closure, a 7 cm × 4 cm size fistula repair product (G13181) (http://www.cookmedical.com/sur/dataSheet.do?id = 5643) was used.…”

Section: Discussionmentioning

confidence: 99%

Traumatic rectourethral fistula repair: A potential application of porcine small intestinal submucosa

et al. 2013

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Rectourethral fistula is an uncommon but devastating condition. Traumatic rectourethral fistula is still uncommon and repair of traumatic rectourethral fistula involves a complex procedure. Most of the urologists would prefer to repair the fistula through perineal route especially when urethral reconstruction is also required. The repaired ends of the fistula are separated with various interposition flaps and grafts in order to prevent recurrence. Gracilis interposition muscle flap is commonly used. We describe the first case of traumatic rectourethral fistula repair in a 45-year-old man using interposition of a porcine small intestinal submucosal (Biodesign™ (Surgisis®) graft.

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“…In order to mimic the unique composition of tissues as closely as possible, researchers have developed several techniques that closely capture the in vivo microenvironment by using decellularized tissues or cell-derived ECM proteins. The usage of decellularized tissues and organs have become increasingly frequent in both pre-clinical animal studies and in human clinical applications [139][140][141]. Decellularization protocols to efficiently remove all cellular and nuclear material include a combination of physical, chemical, and enzymatic approaches, and have been expertly reviewed elsewhere [142].…”

Section: Decellularized Tissue Scaffolds and Cell-derived Ecms For Us...mentioning

confidence: 99%

From de novo peptides to native proteins: advancements in biomaterial scaffolds for acute ischemic stroke repair

Tang

Lampe²

2018

Biomed. Mater.

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An active area of research in the field of regenerative medicine involves the development of bioactive matrices that can promote cellular interactions and elicit desirable regenerative behavior in vivo. This is particularly important in the context of ischemic stroke where a focal lesion forms forestalling the regrowth of brain tissue. Protein-based molecules have been used as building blocks to create supramolecular structures that emulate the properties of the native healthy extracellular matrix (ECM) within the central nervous system (CNS). In this review, we briefly describe the relevant biological aspect of stroke and the techniques found in molecular biology and biochemical synthesis methodologies used in the design and synthesis of novel biomaterials. Within these biomaterials, researchers are able to incorporate a number of different domains that trigger assembly or promote cell growth and survival and direct transplanted or endogenous stem cell behavior within the 3D scaffolds. Such domains may also yield stimuli-responsive biomaterial scaffolds where the structure of the hydrogel undergoes a change in response to the local environment. These highly modular proteinaceous materials allow incorporation of diverse biofunctional motifs and structural elements comparable to those found in native ECM. We explore CNS relevant biomaterials that promote cell survival and host tissue integration and discuss their applications to stem cell therapy in the treatment of stroke.

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A modified technique for the surgical correction of urethral diverticula using a porcine xenograft

Cited by 9 publications

References 5 publications

Complex pelvic floor failure and associated problems

Complex pelvic floor failure and associated problems

Traumatic rectourethral fistula repair: A potential application of porcine small intestinal submucosa

From de novo peptides to native proteins: advancements in biomaterial scaffolds for acute ischemic stroke repair

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