A modified single-prolonged stress model for post-traumatic stress disorder

Wang, Wen; Liu, Yu; Hong, Zhao; Wang, Hua Ning; Xiang, Jun; Chen, Yun Chun; Li, Zheng; Luo, Xianfu; Tan, Qing Rong

doi:10.1016/j.neulet.2008.06.031

Cited by 105 publications

(73 citation statements)

References 10 publications

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“…In fact, several recent studies have demonstrated the efficacy of SSRIs on PTSD-like symptoms in SPS rats. [36,58,59] Takahashi et al showed that 14-day oral administration of paroxetine (PRX) immediately after exposure to SPS, at a dose sufficient to produce clinically relevant serum concentrations, was effective in the prevention of enhanced contextual freezing in SPS rats. [36] Interestingly, acute administration of PRX at a dose that resulted in clinically relevant serum concentrations did not affect enhanced freezing.…”

Section: Sps As An Animal Model Of Ptsdmentioning

confidence: 99%

“…Wang et al have also demonstrated the efficacy of PRX on PTSD-like symptoms in a modified SPS model. [59] In their study, a single electric footshock was given to rats immediately after administration of SPS (SPS1Shock). PRX administered for 14 days immediately after SPS1Shock prevented the induction of PTSD-like symptoms such as enhanced conditioning fear responses and anxiety behaviors.…”

Section: Sps As An Animal Model Of Ptsdmentioning

confidence: 99%

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Single prolonged stress: toward an animal model of posttraumatic stress disorder

et al. 2009

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Although selective serotonin reuptake inhibitors (SSRIs) are reported to be effective in decreasing posttraumatic stress disorder (PTSD) symptoms, a subgroup of PTSD patients remain chronically symptomatic and maintain conditioned fear responses to traumatic stimuli. In this context, the establishment of an appropriate animal model of PTSD is necessary to promote better understanding of the mechanisms of the disorder and to facilitate the development of more effective therapeutic alternatives to SSRIs. Although no single widely accepted animal model of PTSD has been established to date, the single prolonged stress (SPS) animal model has been partially validated as a model for PTSD. SPS rats mimic the pathophysiological abnormalities and behavioral characteristics of PTSD, such as enhanced anxiety-like behavior and glucocorticoid negative feedback, and they exhibit the expected therapeutic response to paroxetine on enhanced fear memory. In addition, SPS rats exhibit enhanced freezing in response to contextual fear conditioning, and impaired extinction of fear memory, which is alleviated by D-cycloserine. The enhanced consolidation and impaired extinction of fear memory found in SPS rats suggests that this model has additional value because recent studies of PTSD indicate that memory abnormalities are a central feature. In this study, we summarize the behavioral and pathophysiological PTSD-like symptoms in SPS, focusing on memory abnormalities, and evaluate the validity of SPS as an animal model of PTSD.

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Section: Sps As An Animal Model Of Ptsdmentioning

confidence: 99%

Section: Sps As An Animal Model Of Ptsdmentioning

confidence: 99%

Single prolonged stress: toward an animal model of posttraumatic stress disorder

et al. 2009

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“…The detailed procedures for the SPS&S procedure were described in previous report [18]. Briefly, rats were restrained for 2 h immediately followed by 20 min forced swimming in 24°C water.…”

Section: Spsands Animal Modelmentioning

confidence: 99%

“…These changes support the validity of SPS as an animal model of PTSD. Our recent work demonstrated that an inescapable foot electric shock added to a classic SPS model (SPS & electric foot shock, SPS&S) significantly enhances fear responses [18] offering a novel PTSD model. This improved model offers significant changes in open field, elevated plus-maze, and Morris water maze performance reflecting increased anxiety-like behaviors [19] and intrusive memory [20] which are characteristic features of PTSD.…”

Section: Introductionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder

et al. 2017

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“…This is another rodent model of PTSD that has been reported in the literature to have lasting behavioral effects (Khan & Liberzon, 2004;Wang et al, 2008). The original published procedure involved sequential application of three acute stressors in a single session: immobilization, forced swim, and then anesthesia were used as stressors (Wang et al, 2008,).…”

Section: Test and Adjust The Sps Model -New Task 1 In Revised Sowmentioning

confidence: 99%

Post-Stress Combined Administration of Beta-Receptor and Glucocorticoid Antagonists as a Novel Preventive Treatment in an Animal Model of PTSD

Morilak¹

2010

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)US ARMY MEDICAL RESEARCH AND MATERIEL COMMAND SPONSOR/MONITOR'S REPORTFORT DETRICK, MD 21702-5012 NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTES14. Many PTSD symptoms reflect pathologically enhanced memory of traumatic stress. Stress-induced secretion of brain norepinephrine and glucocorticoids (GC) activate β-receptors and GC-receptors in the amygdala, enhancing consolidation of emotional memories. We hypothesized that giving a β-antagonist plus a GC-antagonist immediately after stress might decrease the strength of those associations, and prevent the emergence of PTSD. The goals of this work were to 1) validate a reliable model of PTSD amenable to testing acute drug treatment; 2) establish a reliable and valid test battery of PTSD-like behaviors in rats, including fear conditioning and extinction; and 3) test the combined drug treatment using the established model. Although we developed a reliable test battery for PTSD-like behavior, it proved more challenging to establish a consistent, reliable and valid model inducing PTSD-like behaviors. The proposed massed footshock model, derived from the literature, failed to affect the most relevant behavioral measures, and confounded fear conditioning. A modified Single Prolonged Stress model, also from the literature, was more promising but had only modest effects. Early results using a new combined Chronic + Acute Prolonged Stress (CAPS) model, incorporating both chronic and acute features of stress often associated with PTSD, were very promising, but mixed results were obtained with the acute drug interventions. Propranolol had no effect, and mifepristone had only a modest effect on extinction. Nonetheless, this project has been very productive, as we will continue to use this model in other ongoing studies. If PTSD is indeed best modeled by a combined chronic + acute stress, acute drug intervention may not be a feasible strategy. SUBJECT TERMSchronic and acute stress, PTSD, open field t...

show abstract

A modified single-prolonged stress model for post-traumatic stress disorder

Cited by 105 publications

References 10 publications

Single prolonged stress: toward an animal model of posttraumatic stress disorder

Single prolonged stress: toward an animal model of posttraumatic stress disorder

Repetitive transcranial magnetic stimulation ameliorates anxiety-like behavior and impaired sensorimotor gating in a rat model of post-traumatic stress disorder

Post-Stress Combined Administration of Beta-Receptor and Glucocorticoid Antagonists as a Novel Preventive Treatment in an Animal Model of PTSD

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