A modified self‐controlled case series method to examine association between multidose vaccinations and death

Kuhnert, Ronny; Hecker, Hartmut; Poethko‐Müller, Christina; Schlaud, Martin; Vennemann, Mechtild; Whitaker, Heather; Farrington, Paddy

doi:10.1002/sim.4120

Cited by 32 publications

(42 citation statements)

References 35 publications

(36 reference statements)

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“…Authors should report this issue and the potential impact on results. Specificity of case-only design planning in pharmacoepidemiology remains an issue to be discussed and investigated thoroughly in the future [25], [27], [29]–[31]. We also found that results reporting often lacks key elements and impedes the assessment of the internal validity of the case-only analyses.…”

Section: Discussionmentioning

confidence: 83%

Case-Only Designs in Pharmacoepidemiology: A Systematic Review

et al. 2012

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BackgroundCase-only designs have been used since late 1980’s. In these, as opposed to case-control or cohort studies for instance, only cases are required and are self-controlled, eliminating selection biases and confounding related to control subjects, and time-invariant characteristics. The objectives of this systematic review were to analyze how the two main case-only designs – case-crossover (CC) and self-controlled case series (SCCS) – have been applied and reported in pharmacoepidemiology literature, in terms of applicability assumptions and specificities of these designs.Methodology/Principal FindingsWe systematically selected all reports in this field involving case-only designs from MEDLINE and EMBASE up to September 15, 2010. Data were extracted using a standardized form. The analysis included 93 reports 50 (54%) of CC and 45 (48%) SCCS, 2 reports combined both designs. In 12 (24%) CC and 18 (40%) SCCS articles, all applicable validity assumptions of the designs were fulfilled, respectively. Fifty (54%) articles (15 CC (30%) and 35 (78%) SCCS) adequately addressed the specificities of the case-only analyses in the way they reported results.Conclusions/SignificanceOur systematic review underlines that implementation of CC and SCCS designs needs to be more rigorous with regard to validity assumptions, as well as improvement in results reporting.

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Section: Discussionmentioning

confidence: 83%

Case-Only Designs in Pharmacoepidemiology: A Systematic Review

et al. 2012

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“…This explains sudden death from snake bites [321,322], vaccines [323][324][325][326][327][328][329][330][331][332][333], and cocaine [215], in otherwise healthy people, as examples. Depending on their surfactant property and their position within the Hofmeister series, environmental biological or chemical intoxicants of virtually any type can provide the EIWS to induce SDS.…”

Section: Discussionmentioning

confidence: 99%

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Davidson¹,

Seneff²

2012

Entropy

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Abstract:In reviewing the literature pertaining to interfacial water, colloidal stability, and cell membrane function, we are led to propose that a cascade of events that begins with acute exogenous surfactant-induced interfacial water stress can explain the etiology of sudden death syndrome (SDS), as well as many other diseases associated with modern times. A systemic lowering of serum zeta potential mediated by exogenous cationic surfactant administration is the common underlying pathophysiology. The cascade leads to subsequent inflammation, serum sickness, thrombohemorrhagic phenomena, colloidal instability, and ultimately even death. We propose that a sufficient precondition for sudden death is lowered bioavailability of certain endogenous sterol sulfates, sulfated glycolipids, and sulfated glycosaminoglycans, which are essential in maintaining biological equipose, energy metabolism, membrane function, and thermodynamic stability in living organisms. Our literature review provides the basis for the presentation of a novel hypothesis as to the origin of endogenous bio-sulfates which involves energy transduction from sunlight. Our hypothesis is amply supported by a growing body of data showing that parenteral administration of substances that lower serum zeta potential results in kosmotropic cationic and/or chaotropic anionic interfacial water stress, and the resulting cascade.Keywords: inflammation; serum sickness; colloidal instability; interfacial water stress; bio-sulfates; Shwartzman phenomena; sudden death syndrome Glossary of TermsAnaphylaxis a severe, rapidly progressing, life-threatening, generalized allergic reaction. Biological equipoise a stable, non-equilibrium, dissipative system synonymous with life. Cholesterol sulfate (Ch-S)quantitatively the most important known sterol sulfate in human plasma where it regulates the activity of the serine proteases, in cell membranes where it has a stabilizing role, and in platelet membranes where it supports platelet adhesion. Coherence domain (CD)a water CD is a collection of liquid water molecules which oscillate in unison in tune with a self-trapped electromagnetic field at a well-defined frequency. The coherent oscillations produce an ensemble of quasi-free electrons, able to collect noise energy from the environment and transform it into high-grade coherent energy in the form of electron vortices. This high-grade energy may then activate biomolecules resonating with the water CD. Colloidal instabilitya property attributed to a colloidal suspension that develops when stabilizing repulsive steric and electrostatic forces between colliding particles are insufficient to prevent their natural tendency to aggregate into masses large enough to precipitate.Colloidal suspension a colloid that has a continuous liquid phase in which a solid is suspended in a liquid, e.g., our flowing blood. Exclusion zone (EZ)a glass-like, gel phase consisting of water CDs resonating in-phase, adjacent to hydrophilic surfaces, several hundred micrometers wide which excludes colloi...

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“…Researchers in Italy [92] report that the first vaccination carries an increased risk to SIDS in infants. In [93], through statistical analysis based on 300 cases of unexplained sudden death, a 16-fold increased risk was determined following the fourth dose in a series of vaccinations. In [94], it was reported that the observed rate of anaphylaxis following administration of the HPV vaccine to females aged 12 to 26 was significantly higher than the rate observed following other vaccines.…”

Section: Other Related Workmentioning

confidence: 99%

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Seneff

Davidson²,

Liu

2012

Entropy

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Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.

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A modified self‐controlled case series method to examine association between multidose vaccinations and death

Cited by 32 publications

References 35 publications

Case-Only Designs in Pharmacoepidemiology: A Systematic Review

Case-Only Designs in Pharmacoepidemiology: A Systematic Review

The Initial Common Pathway of Inflammation, Disease, and Sudden Death

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

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