A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326

Kaliora, Andriana C.; Kalafati, Ioanna Panagiota; Gioxari, Aristea; Diolintzi, Anastasia; Kokkinos, Alexandros; Dedoussis, George

doi:10.1007/s00394-017-1499-7

Cited by 11 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have explored the interaction between GCKR rs1260326 variant and the environmental factors [74,76,77]. In an open-labeled and single-arm clinical trial, Kaliora et al demonstrated that T allele carriers respond better to nutritional intervention in terms of fasting blood glucose levels compared to non-carriers, in 44 overweight adults with NAFLD which have been received dietary counseling for six months [76]. For instance, whole-grain supplementation is associated with lower fasting glucose and insulin concentrations independently of demographics, other dietary and lifestyle factors and BMI [78].…”

Section: Gckr: a Potential Carbohydrates' Modulator To Improve Liver mentioning

confidence: 99%

Nutrition and Genetics in NAFLD: The Perfect Binomium

Meroni

Longo

Rustichelli

et al. 2020

IJMS

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as 'nutritional genomics,' which encompasses both 'nutrigenetics' and 'nutriepigenomics.' It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management.

show abstract

Section: Gckr: a Potential Carbohydrates' Modulator To Improve Liver mentioning

confidence: 99%

Nutrition and Genetics in NAFLD: The Perfect Binomium

Meroni

Longo

Rustichelli

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Currently there is an absence of safe and effective pharmacotherapies to treat or manage NAFLD and the current recommended therapy is lifestyle intervention to elicit weight loss [15,16]. The optimal dietary pattern has not been explicitly identified and additional high-quality research is needed [17]. However, the limited literature to date suggests that a Mediterranean diet may be superior in the prevention and management of NAFLD [18].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Path of Mediterranean Diet, Non-Alcoholic Fatty Liver Disease (NAFLD) and Inflammation towards 10-Year Cardiovascular Disease (CVD) Risk: The ATTICA Study 10-Year Follow-Up (2002–2012)

et al. 2022

View full text Add to dashboard Cite

Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease, affecting ~30% of the population and increasing CVD. This study aimed to explore the direct, indirect and combined effects of Mediterranean diet, NAFLD and inflammation on the 10-year CVD risk in a healthy adult population. Methods: Using baseline and 10-year follow-up data from the ATTICA study, adherence to Mediterranean diet was measured using MedDietScore, and presence of NAFLD at baseline was assessed using the fatty liver index (FLI). Participants’ 10-year CVD outcomes were recorded and C-reactive protein (CRP) was used as a surrogate marker for inflammation. The direct and indirect roles of these factors were explored using logistic regression models and the pathways between them were analysed using a structural equation model (SEM). Results: NAFLD prevalence was 22.9% and its presence was 17% less likely for every unit increase in MedDietScore. NAFLD presence at baseline was associated with increased 10-year CVD incidence (39.4% vs. 14.5%, p = 0.002), but when adjusted for MedDietScore, NAFLD was not an independent predictor of 10-year CVD risk. MedDietScore was an independent protective factor of 10-year CVD risk (OR = 0.989, 95% CI: 0.847, 0.935), when adjusted for NAFLD at baseline, age, gender, sedentary lifestyle and other confounders. Further exploration using SEM showed that MedDietScore was associated with CVD risk directly even when inflammation as CRP was introduced as a potential mediator. Conclusion: FLI as a proxy measure of NAFLD is a strong predictor of 10-year CVD risk, and this prognostic relationship seems to be moderated by the level of adherence to Mediterranean diet. Adherence to Mediterranean diet remained an independent and direct CVD risk factor irrespective of NAFLD status and CRP.

show abstract