A modified protocol for studying filaggrin degradation using a reconstructed human epidermis model under low and high humidity
Qilong Chen,
Ning Wei,
Yina Lu
Abstract:BackgroundFilaggrin (FLG) is an essential protein that plays a vital role in maintaining skin barrier function and moisture levels, allowing the skin to adapt to dry environments. However, the precise temporal dynamics of FLG metabolism in the human epidermis remain poorly understood, and suitable tools to study these time‐dependent effects are currently lacking.ObjectiveTo investigate the molecular mechanisms and time course of FLG metabolism and skin barrier function under high‐ and low‐humidity conditions, … Show more
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