A modified method for examining the cardiac conduction system

Song, Yue; Zhu, Jun; Laaksonen, Hunnu; Saukko, Pekka

doi:10.1016/s0379-0738(97)00047-9

Cited by 16 publications

(8 citation statements)

References 6 publications

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“…We think that it may be a result of the differences between the regional dietary habits as well as the higher average age in our study (2,(12)(13)(14)28 (12,13,18,29 (4,13,(30)(31)(32)(33)(34) (14,21,(42)(43)(44) (2,13,16,26,27,46 …”

Section: Methodsmentioning

confidence: 77%

Evaluation Of Cardiac Conduction System In Sudden Deaths

Zhao

Zhang²,

Li³

2013

Adli Tip Derg

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Objective:In this study, revealing the regional characteristics of the cardiac conduction system pathologies in sudden death cases is aimed. Besides, this is the first study of Adana region forensic cases related to the cardiac conduction system pathologies. Methods:Twenty seven cases of sudden unexpected death and 4 cases with known causes of death as a control group have been included in the study. Samples from sinoatrial node and atrioventicular node were taken in total 31 cases. Samples were evaluated with light microscope after staining through histochemical staining methods. Results:There were significant pathological changes of the sinoatrial node and atrioventricular node in 10 of the cases. And in 3 of all cases (11.1%), the abnormalities of the conduction system were considered to have the possibility for causing death. Conclusion:We have concluded that it is of importance to evaluate the cardiac conduction system in sudden unexpected death cases and this topic should be kept in sight in forensic pathology.Key words: forensic pathology, cardiac conduction system, sudden death, autopsy ÖZET Amaç:Bu çalışmada, ani kardiyak ölüm vakalarında kardiyak ileti sistemi patolojilerinin bölgesel özelliklerinin ortaya konması amaçlandı. Ayrıca bu çalışma, kardiyak ileti sistemi patolojileri konusunda Adana bölgesindeki adli olgularda yapılan ilk çalış-madır. Yöntemler:Yirmi yedi ani-beklenmedik ölüm olgusu ile ölüm nedeni bilinen 4 olgu kontrol grubu olarak çalışmaya alındı. Toplam 31 olguda, sinoatrial nod ve atrioventriküler nod bölgelerinden örnekler alındı. Örnekler histokimyasal boyama yöntemleri ile boyanarak ışık mikroskobunda incelendi. Bulgular:Ani-beklenmedik ölüm olgularının 10'unda sinoatrial nod ve atrioventriküler nodda belirgin patolojik bulgular saptandı. Tüm olguların 3'ünde (%11,1), ileti sistemi anomalilerinin ölüme neden olabileceği düşünüldü. Sonuç:Ani beklenmedik ölüm olgularında kardiyak ileti sistemi değerlendirmesinin önemli olduğu ve adli patolojide bu konunun göz önünde bulundurulması gerektiği sonucuna vardık. (2,13,14,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) Grade I (+): Irregular widening of the myofibrils or small amounts of fibrosis, adipose tissue infiltration less than 25%, random mono nuclear cellular accumulation.Grade II (++): Small amounts of irregular fibrous tissues and irregular myofibrils, 25-50% of adipose tissue infiltration, 25-50% luminal obliteration of the arteries, accumulations of mono nuclear cellular infiltration. 2,13,28). We think that it may be a result of the differences between the regional dietary habits as well as the higher average age in our study (2,(12)(13)(14)28 (12,13,18,29 (4,13,(30)(31)(32)(33)(34) (14,21,(42)(43)(44) (2,13,16,26,27,46 271. Gordon I, Shapiro HA. Forensic Medicine, 2nd Ed., Edinburg, London, Melbourne, New York: Longman Group Limited, 1982. 2. Cohle SD, Saurez-Mier MP, Aguilera B. Sudden death resulting from lesions of the cardiac conduction system. Am J Foren Med Path 2002;23:83-9. 3. Denfield SW...

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Section: Methodsmentioning

confidence: 77%

Evaluation Of Cardiac Conduction System In Sudden Deaths

Zhao

Zhang²,

Li³

2013

Adli Tip Derg

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“…In 22.2% of these inconclusive cases, the examination of the CCS disclosed pathological changes. Although many simplified methods of the CCS analysis have been proposed, 42,43 an accurate evaluation of findings needs a laborious and expensive procedure that should be carried out with caution because unspecific (fibro-fatty infiltration) and ageing-related changes (calcification, fibro-fatty, etc.) may be common.…”

Section: Discussionmentioning

confidence: 99%

An autopsy study of sudden cardiac death in persons aged 1–40 years in Brescia (Italy)

Vassalini

Verzeletti

Restori

et al. 2016

Journal of Cardiovascular Medicine

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Our study underlines the value of an accurate routine post mortem investigation that may show an otherwise unsuspected structural heart disease. The serial study of the conduction tissue may provide pathologic substrates that may be responsible for the arrhythmic cause of death. A meaningful percentage of cases (22%) had no evidence of any abnormality. Genetic testing can be indicated in these cases.

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“…Gulino and Ottaviani [7,8] use the classical approach, with several hundred slides to study. Song et al [5] uses the same tissue sampling but a longitudinal sectioning instead of perpendicular to the tricuspid valve annulus. Michaud samples only the AV node, its parts and the His bundle with its branches.…”

Section: Discussionmentioning

confidence: 99%

“…After gross heart examination, we sampled the CCS according to the procedure described in the literature [5][6][7][8]. We used a right-sided approach.…”

Section: Methodsmentioning

confidence: 99%