A modified double dye injection method for pulmonary blood volume determination. I. Validation in dogs

Lockhart, A; Vallois, J M; MENSCH-DECHENE, J.; Polianski, J; Zelter, Marc; Sibille, L.

doi:10.1093/cvr/8.1.112

Cited by 2 publications

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“…This group included 78 subjects from 15 studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. From these studies, we analysed available data on mPAP and CO at rest and at maximal supine exercise.…”

Section: Historical Healthy Volunteers Groupmentioning

confidence: 99%

Criteria for diagnosis of exercise pulmonary hypertension

et al. 2015

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The previous definition of exercise pulmonary hypertension (PH) with a mean pulmonary artery pressure (mPAP) >30 mmHg was abandoned because healthy individuals can exceed this threshold at high cardiac output (CO). We hypothesised that incorporating assessment of the pressure-flow relationship using the mPAP/CO ratio, i.e. total pulmonary resistance (TPR), might enhance the accuracy of diagnosing an abnormal exercise haemodynamic response.Exercise haemodynamics were evaluated in 169 consecutive subjects with normal resting mPAP ⩽20 mmHg. Subjects were classified into controls without heart or lung disease (n=68) versus patients with pulmonary vascular disease (PVD) (n=49) and left heart disease (LHD) (n=52).TPR and mPAP at maximal exercise produced diagnostic accuracy with area under the receiver operating curve of 0.99 and 0.95, respectively, for discriminating controls versus patients with PVD and LHD. The old criterion of mPAP >30 mmHg had sensitivity of 0.98 but specificity of 0.77. Combining maximal mPAP >30 mmHg and TPR >3 mmHg·min·L −1 retained sensitivity at 0.93 but improved specificity to 1.0. The accuracy of the combined criteria was high across different age groups, sex, body mass index and diagnosis (PVD or LHD).Combining mPAP >30 mmHg and TPR >3 mmHg·min·L −1 is superior to mPAP >30 mmHg alone for defining a pathological haemodynamic response of the pulmonary circulation during exercise. @ERSpublications Mean PAP >30 mmHg and total pulmonary resistance >3 WU may be used as new criteria for exercise PH

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Section: Historical Healthy Volunteers Groupmentioning

confidence: 99%

Criteria for diagnosis of exercise pulmonary hypertension

et al. 2015

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“…Pulmonary blood volume (PBV) was computed from the dye dilution curves according to Lockhart et al (1974). This technique substitutes for the left atrial injection an injection into the catheter wedged in a distal pulmonary artery.…”

Section: Computed Variablesmentioning

confidence: 99%

Pulmonary arterial wedge pressure measurement can modify pulmonary hae mo dynamics in patients with chronic lung disease

Schrijen¹,

A²,

Chabo³

1993

Clinical Physiology

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In 20 patients with chronic lung disease in stable condition, haemodynamic values were compared during wedging of a Swan-Ganz catheter, either in a distal branch of the pulmonary artery, or by balloon inflation (with 1 ml) in a proximal branch, mostly excluding right lower lobe perfusion. Average pulmonary arterial wedge pressure, systemic arterial pressure, transcutaneous and mixed venous oxygen saturation, cardiac output and pulmonary blood volume (PBV) were not statistically different during distal and proximal wedging, but systolic pulmonary arterial pressure and pulmonary vascular resistance were slightly higher during balloon inflation (P < 0.05). In four patients, PBV decreased by 20% or more; cardiac output was reduced and mean systemic arterial pressure diminished by 10 mmHg or more in three patients. Of the two patients with the lowest PBV, one did not tolerate the balloon inflation because of dyspnoea, and the other showed dramatically haemodynamic changes. These were more likely to occur when the occlusion lead to the exclusion of a still well perfused area. Our results support optimal matching between ventilation and perfusion in patients with chronic lung disease, although both are inhomogeneous. When pulmonary vascular restriction can be suspected, pressure obtained during catheter wedging by balloon inflation should be interpreted with caution. Monitoring arterial oxygen saturation and systemic arterial pressure before and during the manoeuver could help to diagnose haemodynamic effects of the balloon inflation in a proximal pulmonary artery.

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A modified double dye injection method for pulmonary blood volume determination. I. Validation in dogs

Cited by 2 publications

References 0 publications

Criteria for diagnosis of exercise pulmonary hypertension

Criteria for diagnosis of exercise pulmonary hypertension

Pulmonary arterial wedge pressure measurement can modify pulmonary hae mo dynamics in patients with chronic lung disease

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