A modified dialyzer with vitamin E and antioxidant defense parameters

Mydlík, M; Derzsiová, K; Rácz, Olivér; Sipulová, A; Lovásová, Eva; Petrovicová, J

doi:10.1046/j.1523-1755.2001.59780144.x

Cited by 31 publications

(36 citation statements)

References 14 publications

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“…Similar protection of neutrophil function was observed with the vitamin E dialyzer by Omata et al [44]. Mydlik et al [45] found that the vitamin E dialyzer decreased plasma MDA levels.…”

Section: Vitamin-e-coated Dialyzer: Potential Benefitssupporting

confidence: 68%

Current Studies on Oxidant Stress in Dialysis

Handelman

2003

Blood Purif

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Breath ethane measurements in hemodialysis indicate that a portion of these patients suffer increased oxidant stress, consistent with findings using other methods for oxidant stress determination. Loosely-bound iron definitely appears in the bloodstream when substantial doses of IV iron are administered, since transferrin is fully saturated, but our investigations generally do not show short-term oxidant stress from this treatment. If small doses of IV iron are utilized, transferrin saturation can be avoided, and risk is minimized. The vitamin C status of hemodialysis patients is usually lower than the general population, and the impact of this deficiency must be assessed in controlled investigations. Various interventions, including the vitamin E-bonded dialyzer and dietary antioxidant supplements, may ameliorate a portion of the oxidant stress in hemodialysis patients.

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“…Similar protection of neutrophil function was observed with the vitamin E dialyzer by Omata et al [44]. Mydlik et al [45] found that the vitamin E dialyzer decreased plasma MDA levels.…”

Section: Vitamin-e-coated Dialyzer: Potential Benefitssupporting

confidence: 68%

Current Studies on Oxidant Stress in Dialysis

Handelman

2003

Blood Purif

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“…Changes in plasma and RBC glutathione peroxidase (GSH-PX) activities were reported in 3 [11,26,44] and 5 studies [36,44,49,55,58] , respectively. Data on RBC superoxide dismutase (SOD) activity were available in 5 studies [11,26,49,55,58] .…”

Section: Outcome Datamentioning

confidence: 99%

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

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Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

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“…To address this issue, several groups recently focused on developing hemodialysis membranes with antioxidative properties. The most commonly used approach is to immobilize antioxidants, such as vitamin E [1][2][3], linoleic acid [4][5][6][7], soybean-derived phytochemical, genistein [8] and alpha lipoic acid [9], on surfaces of the membranes that are in contact with blood. Antioxidant immobilization did not only allow for the inhibition of reactive oxygen species (ROS) generation but also reduced platelet adhesion and protein adsorption and prolonged blood coagulation time [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Immobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methods

Mahlicli

Şen

Mutlu

et al. 2015

Journal of Membrane Science

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a b s t r a c tThe objective of this study is to improve the blood compatibility of polysulfone (PSF) based hemodialysis membranes through generating antioxidative surfaces with superoxide dismutase (SOD)/catalase (CAT) enzyme couple immobilization. Enzymes were attached both covalently and ionically on the plasma treated and polyethyleneimine (PEI) deposited membranes, respectively. The loss of enzymes from PEI modified surface at the end of 4 h was found to be relatively higher during storage in phosphate buffered saline (PBS) at pH 7.4 when compared to the enzymes on the plasma treated surface. The kinetic studies indicated that SOD catalyzed the reaction in the diffusion-limited regime at all substrate concentrations and its inactivation by hydrogen peroxide was prevented in the presence of CAT. SOD/CAT coated PSF membranes were capable of reducing the levels of reactive oxygen species in blood and can significantly prolong activated partial thromboplastin time. In addition, both the adsorption of human plasma proteins and platelet activation on all modified membranes decreased significantly compared to the unmodified PSF membranes. Proposed modification methods did not affect high permeability, high mechanical strength or the non-toxic properties of the PSF membranes.

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A modified dialyzer with vitamin E and antioxidant defense parameters

Abstract: The results of our study suggest that the modified dialyzer with vitamin E provided more effective antioxidant defense than peroral administration of vitamin E in our hemodialysis patients.

Cited by 31 publications

References 14 publications

Current Studies on Oxidant Stress in Dialysis

Current Studies on Oxidant Stress in Dialysis

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Immobilization of superoxide dismutase/catalase onto polysulfone membranes to suppress hemodialysis-induced oxidative stress: A comparison of two immobilization methods

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